PAMPs and DAMPs: signal 0s that spur autophagy and immunity.

Journal Article (Journal Article;Review)

Pathogen-associated molecular pattern molecules (PAMPs) are derived from microorganisms and recognized by pattern recognition receptor (PRR)-bearing cells of the innate immune system as well as many epithelial cells. In contrast, damage-associated molecular pattern molecules (DAMPs) are cell-derived and initiate and perpetuate immunity in response to trauma, ischemia, and tissue damage, either in the absence or presence of pathogenic infection. Most PAMPs and DAMPs serve as so-called 'Signal 0s' that bind specific receptors [Toll-like receptors, NOD-like receptors, RIG-I-like receptors, AIM2-like receptors, and the receptor for advanced glycation end products (RAGE)] to promote autophagy. Autophagy, a conserved lysosomal degradation pathway, is a cell survival mechanism invoked in response to environmental and cellular stress. Autophagy is inferred to have been present in the last common eukaryotic ancestor and only to have been lost by some obligatory intracellular parasites. As such, autophagy represents a unifying biology, subserving survival and the earliest host defense strategies, predating apoptosis, within eukaryotes. Here, we review recent advances in our understanding of autophagic molecular mechanisms and functions in emergent immunity.

Full Text

Duke Authors

Cited Authors

  • Tang, D; Kang, R; Coyne, CB; Zeh, HJ; Lotze, MT

Published Date

  • September 2012

Published In

Volume / Issue

  • 249 / 1

Start / End Page

  • 158 - 175

PubMed ID

  • 22889221

Pubmed Central ID

  • PMC3662247

Electronic International Standard Serial Number (EISSN)

  • 1600-065X

Digital Object Identifier (DOI)

  • 10.1111/j.1600-065X.2012.01146.x

Language

  • eng

Conference Location

  • England