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PAMPs and DAMPs: signal 0s that spur autophagy and immunity.

Publication ,  Journal Article
Tang, D; Kang, R; Coyne, CB; Zeh, HJ; Lotze, MT
Published in: Immunol Rev
September 2012

Pathogen-associated molecular pattern molecules (PAMPs) are derived from microorganisms and recognized by pattern recognition receptor (PRR)-bearing cells of the innate immune system as well as many epithelial cells. In contrast, damage-associated molecular pattern molecules (DAMPs) are cell-derived and initiate and perpetuate immunity in response to trauma, ischemia, and tissue damage, either in the absence or presence of pathogenic infection. Most PAMPs and DAMPs serve as so-called 'Signal 0s' that bind specific receptors [Toll-like receptors, NOD-like receptors, RIG-I-like receptors, AIM2-like receptors, and the receptor for advanced glycation end products (RAGE)] to promote autophagy. Autophagy, a conserved lysosomal degradation pathway, is a cell survival mechanism invoked in response to environmental and cellular stress. Autophagy is inferred to have been present in the last common eukaryotic ancestor and only to have been lost by some obligatory intracellular parasites. As such, autophagy represents a unifying biology, subserving survival and the earliest host defense strategies, predating apoptosis, within eukaryotes. Here, we review recent advances in our understanding of autophagic molecular mechanisms and functions in emergent immunity.

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Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

September 2012

Volume

249

Issue

1

Start / End Page

158 / 175

Location

England

Related Subject Headings

  • Toll-Like Receptors
  • Signal Transduction
  • Receptors, Pattern Recognition
  • Inflammation
  • Infections
  • Immunology
  • Immunity, Innate
  • Immunity
  • Humans
  • Autophagy
 

Citation

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Tang, D., Kang, R., Coyne, C. B., Zeh, H. J., & Lotze, M. T. (2012). PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev, 249(1), 158–175. https://doi.org/10.1111/j.1600-065X.2012.01146.x
Tang, Daolin, Rui Kang, Carolyn B. Coyne, Herbert J. Zeh, and Michael T. Lotze. “PAMPs and DAMPs: signal 0s that spur autophagy and immunity.Immunol Rev 249, no. 1 (September 2012): 158–75. https://doi.org/10.1111/j.1600-065X.2012.01146.x.
Tang D, Kang R, Coyne CB, Zeh HJ, Lotze MT. PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev. 2012 Sep;249(1):158–75.
Tang, Daolin, et al. “PAMPs and DAMPs: signal 0s that spur autophagy and immunity.Immunol Rev, vol. 249, no. 1, Sept. 2012, pp. 158–75. Pubmed, doi:10.1111/j.1600-065X.2012.01146.x.
Tang D, Kang R, Coyne CB, Zeh HJ, Lotze MT. PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev. 2012 Sep;249(1):158–175.
Journal cover image

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

September 2012

Volume

249

Issue

1

Start / End Page

158 / 175

Location

England

Related Subject Headings

  • Toll-Like Receptors
  • Signal Transduction
  • Receptors, Pattern Recognition
  • Inflammation
  • Infections
  • Immunology
  • Immunity, Innate
  • Immunity
  • Humans
  • Autophagy