The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells.

Journal Article (Journal Article;Review)

Many diverse viruses target a polarized epithelial monolayer during host invasion. The polarized epithelium is adept at restricting the movement of solutes, ions, macromolecules, and pathogens across the mucosa. This regulation can be attributed to the presence of a junctional complex between adjacent cells and to an intricate network of actin filaments that provides support to the subapical membrane and stabilizes intercellular junctions. It is therefore not surprising that many viruses have evolved highly varied strategies to dissolve or modulate the cortical actin meshwork to promote infection of polarized cells. In this review, we will discuss the cell biological properties of the actin cytoskeleton in polarized epithelial cells and review the known mechanisms utilized by viral pathogens to manipulate this system in order to facilitate their infection.

Full Text

Duke Authors

Cited Authors

  • Delorme-Axford, E; Coyne, CB

Published Date

  • December 2011

Published In

Volume / Issue

  • 3 / 12

Start / End Page

  • 2462 - 2477

PubMed ID

  • 22355449

Pubmed Central ID

  • PMC3280511

Electronic International Standard Serial Number (EISSN)

  • 1999-4915

Digital Object Identifier (DOI)

  • 10.3390/v3122462

Language

  • eng

Conference Location

  • Switzerland