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The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells.

Publication ,  Journal Article
Delorme-Axford, E; Coyne, CB
Published in: Viruses
December 2011

Many diverse viruses target a polarized epithelial monolayer during host invasion. The polarized epithelium is adept at restricting the movement of solutes, ions, macromolecules, and pathogens across the mucosa. This regulation can be attributed to the presence of a junctional complex between adjacent cells and to an intricate network of actin filaments that provides support to the subapical membrane and stabilizes intercellular junctions. It is therefore not surprising that many viruses have evolved highly varied strategies to dissolve or modulate the cortical actin meshwork to promote infection of polarized cells. In this review, we will discuss the cell biological properties of the actin cytoskeleton in polarized epithelial cells and review the known mechanisms utilized by viral pathogens to manipulate this system in order to facilitate their infection.

Duke Scholars

Published In

Viruses

DOI

EISSN

1999-4915

Publication Date

December 2011

Volume

3

Issue

12

Start / End Page

2462 / 2477

Location

Switzerland

Related Subject Headings

  • rho GTP-Binding Proteins
  • Virus Internalization
  • Tight Junctions
  • Rotavirus
  • Orthomyxoviridae
  • Humans
  • Herpesviridae
  • Epithelial Cells
  • Enterovirus B, Human
  • Cell Polarity
 

Citation

APA
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ICMJE
MLA
NLM
Delorme-Axford, E., & Coyne, C. B. (2011). The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells. Viruses, 3(12), 2462–2477. https://doi.org/10.3390/v3122462
Delorme-Axford, Elizabeth, and Carolyn B. Coyne. “The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells.Viruses 3, no. 12 (December 2011): 2462–77. https://doi.org/10.3390/v3122462.
Delorme-Axford E, Coyne CB. The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells. Viruses. 2011 Dec;3(12):2462–77.
Delorme-Axford, Elizabeth, and Carolyn B. Coyne. “The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells.Viruses, vol. 3, no. 12, Dec. 2011, pp. 2462–77. Pubmed, doi:10.3390/v3122462.
Delorme-Axford E, Coyne CB. The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells. Viruses. 2011 Dec;3(12):2462–2477.

Published In

Viruses

DOI

EISSN

1999-4915

Publication Date

December 2011

Volume

3

Issue

12

Start / End Page

2462 / 2477

Location

Switzerland

Related Subject Headings

  • rho GTP-Binding Proteins
  • Virus Internalization
  • Tight Junctions
  • Rotavirus
  • Orthomyxoviridae
  • Humans
  • Herpesviridae
  • Epithelial Cells
  • Enterovirus B, Human
  • Cell Polarity