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Tissue elasticity using acoustic radiation force

Publication ,  Journal Article
Negron, LA; Walker, WF; Fernandez, FJ
Published in: Proceedings of SPIE - The International Society for Optical Engineering
January 1, 2000

We are developing a method that uses acoustic radiation force to image the stiffness of the vitreous body and other soft materials. This approach applies acoustic radiation force through a series of ultrasonic pulses to generate small displacements in tissue. Motion tracking techniques are used to measure the resultant displacement. This process can be repeated at a number of locations to acquire data for image formation. A series of acrylamide phantoms were constructed to test the proposed method. Phantom speed of sound and attenuation have been characterized and found to be close to that of the human vitreous. In this paper, we present acoustic radiation force images, which clearly distinguish phantoms of differing gel concentration. We also show time-displacement curves, which indicate a viscoelastic response for this material. The images presented show that acoustic radiation force can be used to image tissue mechanical properties including displacement, relative elasticity and relative viscosity. We present data that indicates maximum displacement is linearly proportional to the power transmitted by the system. Optical data was also collected to enable visualization of the displacement field.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

ISSN

0277-786X

Publication Date

January 1, 2000

Volume

3982

Start / End Page

306 / 314

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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Negron, L. A., Walker, W. F., & Fernandez, F. J. (2000). Tissue elasticity using acoustic radiation force. Proceedings of SPIE - The International Society for Optical Engineering, 3982, 306–314.
Negron, L. A., W. F. Walker, and F. J. Fernandez. “Tissue elasticity using acoustic radiation force.” Proceedings of SPIE - The International Society for Optical Engineering 3982 (January 1, 2000): 306–14.
Negron LA, Walker WF, Fernandez FJ. Tissue elasticity using acoustic radiation force. Proceedings of SPIE - The International Society for Optical Engineering. 2000 Jan 1;3982:306–14.
Negron, L. A., et al. “Tissue elasticity using acoustic radiation force.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 3982, Jan. 2000, pp. 306–14.
Negron LA, Walker WF, Fernandez FJ. Tissue elasticity using acoustic radiation force. Proceedings of SPIE - The International Society for Optical Engineering. 2000 Jan 1;3982:306–314.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

ISSN

0277-786X

Publication Date

January 1, 2000

Volume

3982

Start / End Page

306 / 314

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering