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Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients.

Publication ,  Journal Article
Ni, X; Ouyang, W; Jeong, H; Kim, J-T; Tzaveils, A; Mirzazadeh, A; Wu, C; Lee, JY; Keller, M; Mummidisetty, CK; Patel, M; Shawen, N; Huang, J ...
Published in: Proceedings of the National Academy of Sciences of the United States of America
May 2021

Capabilities in continuous monitoring of key physiological parameters of disease have never been more important than in the context of the global COVID-19 pandemic. Soft, skin-mounted electronics that incorporate high-bandwidth, miniaturized motion sensors enable digital, wireless measurements of mechanoacoustic (MA) signatures of both core vital signs (heart rate, respiratory rate, and temperature) and underexplored biomarkers (coughing count) with high fidelity and immunity to ambient noises. This paper summarizes an effort that integrates such MA sensors with a cloud data infrastructure and a set of analytics approaches based on digital filtering and convolutional neural networks for monitoring of COVID-19 infections in sick and healthy individuals in the hospital and the home. Unique features are in quantitative measurements of coughing and other vocal events, as indicators of both disease and infectiousness. Systematic imaging studies demonstrate correlations between the time and intensity of coughing, speaking, and laughing and the total droplet production, as an approximate indicator of the probability for disease spread. The sensors, deployed on COVID-19 patients along with healthy controls in both inpatient and home settings, record coughing frequency and intensity continuously, along with a collection of other biometrics. The results indicate a decaying trend of coughing frequency and intensity through the course of disease recovery, but with wide variations across patient populations. The methodology creates opportunities to study patterns in biometrics across individuals and among different demographic groups.

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Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

May 2021

Volume

118

Issue

19

Start / End Page

e2026610118

Related Subject Headings

  • Wireless Technology
  • SARS-CoV-2
  • Respiratory Sounds
  • Respiratory Rate
  • Monitoring, Physiologic
  • Humans
  • Heart Rate
  • COVID-19
  • Biomarkers
 

Citation

APA
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ICMJE
MLA
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Ni, X., Ouyang, W., Jeong, H., Kim, J.-T., Tzaveils, A., Mirzazadeh, A., … Rogers, J. A. (2021). Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients. Proceedings of the National Academy of Sciences of the United States of America, 118(19), e2026610118. https://doi.org/10.1073/pnas.2026610118
Ni, Xiaoyue, Wei Ouyang, Hyoyoung Jeong, Jin-Tae Kim, Andreas Tzaveils, Ali Mirzazadeh, Changsheng Wu, et al. “Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients.Proceedings of the National Academy of Sciences of the United States of America 118, no. 19 (May 2021): e2026610118. https://doi.org/10.1073/pnas.2026610118.
Ni X, Ouyang W, Jeong H, Kim J-T, Tzaveils A, Mirzazadeh A, et al. Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients. Proceedings of the National Academy of Sciences of the United States of America. 2021 May;118(19):e2026610118.
Ni, Xiaoyue, et al. “Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients.Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 19, May 2021, p. e2026610118. Epmc, doi:10.1073/pnas.2026610118.
Ni X, Ouyang W, Jeong H, Kim J-T, Tzaveils A, Mirzazadeh A, Wu C, Lee JY, Keller M, Mummidisetty CK, Patel M, Shawen N, Huang J, Chen H, Ravi S, Chang J-K, Lee K, Wu Y, Lie F, Kang YJ, Kim JU, Chamorro LP, Banks AR, Bharat A, Jayaraman A, Xu S, Rogers JA. Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients. Proceedings of the National Academy of Sciences of the United States of America. 2021 May;118(19):e2026610118.
Journal cover image

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

May 2021

Volume

118

Issue

19

Start / End Page

e2026610118

Related Subject Headings

  • Wireless Technology
  • SARS-CoV-2
  • Respiratory Sounds
  • Respiratory Rate
  • Monitoring, Physiologic
  • Humans
  • Heart Rate
  • COVID-19
  • Biomarkers