A perspective essay on the use of Ga3+ as a proxy for Fe3+ in bioinorganic model studies and its successful use for therapeutic purposes.

Journal Article (Review;Journal Article)

The use of Ga3+ as a structural mimic for Fe3+ in model bioinorganic investigations is usually based on a common assumption that Ga3+ and Fe3+ should form bioligand complexes of similar stabilities due to their similar charge/radius ratio (z/r). However, the literature survey presented here is contrary to this notion, showing that under laboratory conditions often Ga3+ forms weaker bioligand complexes than Fe3+ in aqueous medium. We hypothesize that this is because Ga3+ is more aquaphilic than Fe3+ as suggested by their relative heats of hydration (ΔHhyd ). The successful use of Ga3+ as a therapeutic agent is also briefly reviewed, showing this success often stems from the redox inertness as well as different pharmacokinetics of Ga3+ than Fe3+ , but similar metabolic pathways as Fe3+ in human serum.

Full Text

Duke Authors

Cited Authors

  • Crumbliss, AL; Banerjee, S

Published Date

  • June 2021

Published In

Volume / Issue

  • 219 /

Start / End Page

  • 111411 -

PubMed ID

  • 33853006

Electronic International Standard Serial Number (EISSN)

  • 1873-3344

International Standard Serial Number (ISSN)

  • 0162-0134

Digital Object Identifier (DOI)

  • 10.1016/j.jinorgbio.2021.111411


  • eng