Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.

Journal Article (Journal Article)

Whereas the human fetal immune system is poised to generate immune tolerance and suppress inflammation in utero, an adult-like immune system emerges to orchestrate anti-pathogen immune responses in post-natal life. It has been posited that cells of the adult immune system arise as a discrete ontological "layer" of hematopoietic stem-progenitor cells (HSPCs) and their progeny; evidence supporting this model in humans has, however, been inconclusive. Here, we combine bulk and single-cell transcriptional profiling of lymphoid cells, myeloid cells, and HSPCs from fetal, perinatal, and adult developmental stages to demonstrate that the fetal-to-adult transition occurs progressively along a continuum of maturity-with a substantial degree of inter-individual variation at the time of birth-rather than via a transition between discrete waves. These findings have important implications for the design of strategies for prophylaxis against infection in the newborn and for the use of umbilical cord blood (UCB) in the setting of transplantation.

Full Text

Duke Authors

Cited Authors

  • Bunis, DG; Bronevetsky, Y; Krow-Lucal, E; Bhakta, NR; Kim, CC; Nerella, S; Jones, N; Mendoza, VF; Bryson, YJ; Gern, JE; Rutishauser, RL; Ye, CJ; Sirota, M; McCune, JM; Burt, TD

Published Date

  • January 5, 2021

Published In

Volume / Issue

  • 34 / 1

Start / End Page

  • 108573 -

PubMed ID

  • 33406429

Electronic International Standard Serial Number (EISSN)

  • 2211-1247

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2020.108573

Language

  • eng

Conference Location

  • United States