Magnetic resonance biomarkers in radiation oncology: The report of AAPM Task Group 294.

Journal Article (Journal Article)

PURPOSE: A magnetic resonance (MR) biologic marker (biomarker) is a measurable quantitative characteristic that is an indicator of normal biological and pathogenetic processes or a response to therapeutic intervention derived from the MR imaging process. There is significant potential for MR biomarkers to facilitate personalized approaches to cancer care through more precise disease targeting by quantifying normal versus pathologic tissue function as well as toxicity to both radiation and chemotherapy. Both of which have the potential to increase the therapeutic ratio and provide earlier, more accurate monitoring of treatment response. The ongoing integration of MR into routine clinical radiation therapy (RT) planning and the development of MR guided radiation therapy systems is providing new opportunities for MR biomarkers to personalize and improve clinical outcomes. Their appropriate use, however, must be based on knowledge of the physical origin of the biomarker signal, the relationship to the underlying biological processes, and their strengths and limitations. The purpose of this report is to provide an educational resource describing MR biomarkers, the techniques used to quantify them, their strengths and weakness within the context of their application to radiation oncology so as to ensure their appropriate use and application within this field.

Full Text

Duke Authors

Cited Authors

  • McGee, KP; Hwang, K-P; Sullivan, DC; Kurhanewicz, J; Hu, Y; Wang, J; Li, W; Debbins, J; Paulson, E; Olsen, JR; Hua, C-H; Warner, L; Ma, D; Moros, E; Tyagi, N; Chung, C

Published Date

  • July 2021

Published In

Volume / Issue

  • 48 / 7

Start / End Page

  • e697 - e732

PubMed ID

  • 33864283

Pubmed Central ID

  • PMC8361924

Electronic International Standard Serial Number (EISSN)

  • 2473-4209

Digital Object Identifier (DOI)

  • 10.1002/mp.14884

Language

  • eng

Conference Location

  • United States