Quality of life and long-term outcomes after hospitalization for COVID-19: Protocol for a prospective cohort study (Coalition VII).
(Journal Article;Multicenter Study)
INTRODUCTION: The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil. METHODS: This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed-up for a period of 1 year by means of structured telephone interviews. The primary outcome is the 1-year utility score of health-related quality of life assessed by the EuroQol-5D3L. Secondary outcomes include all-cause mortality, major cardiovascular events, rehospitalizations, return to work or study, physical functional status assessed by the Lawton-Brody Instrumental Activities of Daily Living, dyspnea assessed by the modified Medical Research Council dyspnea scale, need for long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-Revised, and self-rated health assessed by the EuroQol-5D3L Visual Analog Scale. Generalized estimated equations will be performed to test the association between five sets of variables (1- demographic characteristics, 2- premorbid state of health, 3- characteristics of acute illness, 4- specific COVID-19 treatments received, and 5- time-updated postdischarge variables) and outcomes. ETHICS AND DISSEMINATION: The study protocol was approved by the Research Ethics Committee of all participant institutions. The results will be disseminated through conferences and peer-reviewed journals.
Rosa, RG; Robinson, CC; Veiga, VC; Cavalcanti, AB; Azevedo, LCPD; Machado, FR; Berwanger, O; Avezum, Á; Lopes, RD; Lisboa, TC; Teixeira, C; Zampieri, FG; Tomazini, BM; Kawano-Dourado, L; Schneider, D; Souza, DD; Santos, RDRMD; Silva, SSD; Trott, G; Gimenes, BDP; Souza, APD; Barroso, BM; Costa, LS; Brognoli, LG; Pelliccioli, MP; Studier, NDS; Schardosim, RFDC; Haubert, TA; Pallaoro, VEL; Oliveira, DMD; Velho, PI; Medeiros, GS; Gazzana, MB; Zavascki, AP; Pitrez, PM; Oliveira, RPD; Polanczyk, CA; Nasi, LA; Hammes, LS; Falavigna, M
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