Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III.

Journal Article (Journal Article)

Rhodojaponin III is a grayanane-type diterpenoid natural product with a novel chemical scaffold. It shows potent antinociceptive activity and may represent a new class of natural non-opioid analgesics with a novel mode of action. We explored the Au(I)-catalyzed Conia-ene cyclization and the Mn(III)-mediated radical cyclization of alkynyl ketones for the synthesis of the bicyclo[3.2.1]octane fragment of rhodojaponin III. These strategies will be applicable in the synthesis of rhodojaponin III and analogs for future biological studies.

Full Text

Duke Authors

Hong, Jiyong

Cited Authors

Webster, CG; Park, H; Ennis, AF; Hong, J

Published Date

May 1, 2021

Published In

Tetrahedron Letters

Volume / Issue

71 /

Start / End Page

153055 -

PubMed ID

34054153

Pubmed Central ID

PMC8153367

International Standard Serial Number (ISSN)

0040-4039

Digital Object Identifier (DOI)

10.1016/j.tetlet.2021.153055

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