Metabolic flexibility during late pregnancy is associated with neonatal adiposity.

Journal Article (Journal Article)

The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of "metabolic flexibility". Neonatal adiposity was assessed within 48 h of delivery by skinfold anthropometry. Metabolic flexibility (r = -0.271, p = 0.034), maternal HOMA-IR (r = 0.280, p = 0.030), and maternal body mass index (r = 0.299, p = 0.018) were correlated with neonatal subscapular skinfold (i.e., measure of neonatal adiposity). Clinical Trail Registration Number: NCT03504319. Novelty: This is the first study to link maternal metabolic flexibility, body mass index, and insulin resistance during pregnancy to neonatal adiposity at parturition.

Full Text

Duke Authors

Cited Authors

  • Tinius, RA; Blankenship, MM; Furgal, KE; Cade, WT; Duchette, C; Pearson, KJ; Maples, JM

Published Date

  • April 2021

Published In

Volume / Issue

  • 46 / 4

Start / End Page

  • 404 - 407

PubMed ID

  • 33544662

Pubmed Central ID

  • PMC8158655

Electronic International Standard Serial Number (EISSN)

  • 1715-5320

Digital Object Identifier (DOI)

  • 10.1139/apnm-2020-1005


  • eng

Conference Location

  • Canada