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Low-Grade Cutaneous B-cell Lymphoma in African American Patients.

Publication ,  Journal Article
Geller, S; Pulitzer, M; Myskowski, P; Kheterpal, M
Published in: J Drugs Dermatol
December 1, 2018

Introduction: Cutaneous marginal zone lymphoma (CMZL) and cutaneous follicle center lymphoma (CFCL) are rare indolent cutaneous B-cell lymphomas (CBCL). Their incidence in African American (AA) patients is extremely low. While cutaneous T-cell lymphomas appear to be more aggressive in AA individuals, there is no data on the presentation and course of disease of CBCL in this group. In this study, we aimed to characterize CMZL/CFCL in AA patients. Methods: A retrospective chart review identified 10 AA patients with CMZL/CFCL. We compared demographics, clinical features, and systemic disease incidence between AA and white patients. Results: Of 288 patients with CMZL/CFCL, 10 patients were AA (3.5%), and 266 were white. AA patients trended toward diagnosis at a younger age compared to white individuals (median age of 41 vs 54 years; P=0.07). AAs presented with more regional and generalized cutaneous disease (T2-T3 in 70%), while most white patients presented with a solitary lesion (T1 in 55%). Head and neck involvement was more common in AA patients. Extracutaneous systemic disease at initial staging was not significantly different between the groups. One AA patient with primary CMZL developed extracutaneous MZL after16 years. No deaths were reported among AAs. Discussion: CMZL/ CFCL in this series of AA patients had an earlier age of onset with preferential head and neck involvement and a higher T classification at presentation. Despite these features, systemic involvement was uncommon, and no deaths were recorded. This data supports an indolent course of CMZL and CFCL in the AA population; larger studies are needed to confirm these findings. J Drugs Dermatol. 2018;17(12):1334-1337.

Duke Scholars

Published In

J Drugs Dermatol

ISSN

1545-9616

Publication Date

December 1, 2018

Volume

17

Issue

12

Start / End Page

1334 / 1337

Location

United States

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • New York City
  • Middle Aged
  • Male
  • Lymphoma, B-Cell, Marginal Zone
  • Incidence
  • Humans
  • Female
  • Ethnicity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Geller, S., Pulitzer, M., Myskowski, P., & Kheterpal, M. (2018). Low-Grade Cutaneous B-cell Lymphoma in African American Patients. J Drugs Dermatol, 17(12), 1334–1337.
Geller, Shamir, Melissa Pulitzer, Patricia Myskowski, and Meenal Kheterpal. “Low-Grade Cutaneous B-cell Lymphoma in African American Patients.J Drugs Dermatol 17, no. 12 (December 1, 2018): 1334–37.
Geller S, Pulitzer M, Myskowski P, Kheterpal M. Low-Grade Cutaneous B-cell Lymphoma in African American Patients. J Drugs Dermatol. 2018 Dec 1;17(12):1334–7.
Geller, Shamir, et al. “Low-Grade Cutaneous B-cell Lymphoma in African American Patients.J Drugs Dermatol, vol. 17, no. 12, Dec. 2018, pp. 1334–37.
Geller S, Pulitzer M, Myskowski P, Kheterpal M. Low-Grade Cutaneous B-cell Lymphoma in African American Patients. J Drugs Dermatol. 2018 Dec 1;17(12):1334–1337.

Published In

J Drugs Dermatol

ISSN

1545-9616

Publication Date

December 1, 2018

Volume

17

Issue

12

Start / End Page

1334 / 1337

Location

United States

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • New York City
  • Middle Aged
  • Male
  • Lymphoma, B-Cell, Marginal Zone
  • Incidence
  • Humans
  • Female
  • Ethnicity