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Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk.

Publication ,  Journal Article
Donnelly, CR; Pierchala, BA
Published in: Cell Tissue Res
October 2020

The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) comprise a group of four homologous and potent growth factors that includes GDNF, neurturin (NRTN), artemin (ARTN), and persephin (PSPN). The survival, growth, and mitotic activities of the GFLs are conveyed by a single receptor tyrosine kinase, Ret. The GFLs do not bind directly to Ret in order to activate it, and instead bind with high affinity to glycerophosphatidylinositol (GPI)-anchored coreceptors called the GDNF family receptor-αs (GFRαs). Several mechanisms have recently been identified that influence the trafficking of Ret and GFRαs in and out of the plasma membrane, thereby affecting their availability for ligand binding, as well as their levels by targeting to degradative pathways. This review describes these mechanisms and their powerful effects on GFL signaling and function. We also describe the recent discovery that p75 and Ret form a signaling complex, also regulated by plasma membrane shuttling, that either enhances GFL survival signals or p75 pro-apoptotic signals, dependent on the cellular context.

Duke Scholars

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Published In

Cell Tissue Res

DOI

EISSN

1432-0878

Publication Date

October 2020

Volume

382

Issue

1

Start / End Page

57 / 64

Location

Germany

Related Subject Headings

  • Signal Transduction
  • Protein Transport
  • Neurology & Neurosurgery
  • Humans
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Cell Membrane
  • 3208 Medical physiology
  • 1116 Medical Physiology
 

Citation

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Donnelly, C. R., & Pierchala, B. A. (2020). Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk. Cell Tissue Res, 382(1), 57–64. https://doi.org/10.1007/s00441-020-03235-4
Donnelly, Christopher R., and Brian A. Pierchala. “Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk.Cell Tissue Res 382, no. 1 (October 2020): 57–64. https://doi.org/10.1007/s00441-020-03235-4.
Donnelly CR, Pierchala BA. Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk. Cell Tissue Res. 2020 Oct;382(1):57–64.
Donnelly, Christopher R., and Brian A. Pierchala. “Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk.Cell Tissue Res, vol. 382, no. 1, Oct. 2020, pp. 57–64. Pubmed, doi:10.1007/s00441-020-03235-4.
Donnelly CR, Pierchala BA. Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk. Cell Tissue Res. 2020 Oct;382(1):57–64.
Journal cover image

Published In

Cell Tissue Res

DOI

EISSN

1432-0878

Publication Date

October 2020

Volume

382

Issue

1

Start / End Page

57 / 64

Location

Germany

Related Subject Headings

  • Signal Transduction
  • Protein Transport
  • Neurology & Neurosurgery
  • Humans
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Cell Membrane
  • 3208 Medical physiology
  • 1116 Medical Physiology