Mouse models for actinic keratoses.

Journal Article (Journal Article;Review)

Actinic keratoses (AKs) represent a premalignant skin condition due to chronic sun damage that dramatically increases in prevalence in the aging population. Currently, animal models of AKs utilize photocarcinogenesis, chemical carcinogens, or targeted gene modulation, and each method possesses unique strengths and weaknesses. Models using photodamage most comprehensively describe methods for preferentially selecting AK lesions, while replicating the pathogenesis of AKs with greater fidelity than models utilizing other carcinogenic methods. The following review of current murine models of AKs will aid in the selection of mouse models appropriate for future in vivo studies to test the efficacy of novel therapeutic agents for the treatment of AKs.

Full Text

Duke Authors

Cited Authors

  • Choi, J; West, CE; Roh, YS; Sutaria, N; Kwatra, SG; Kwatra, MM

Published Date

  • July 2021

Published In

Volume / Issue

  • 110 /

Start / End Page

  • 107071 -

PubMed ID

  • 33933627

Electronic International Standard Serial Number (EISSN)

  • 1873-488X

Digital Object Identifier (DOI)

  • 10.1016/j.vascn.2021.107071

Language

  • eng

Conference Location

  • United States