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Polyester Mesh Functionalization with Nitric Oxide-Releasing Silica Nanoparticles Reduces Early Methicillin-Resistant Staphylococcus aureus Contamination.

Publication ,  Journal Article
Fernandez-Moure, JS; Van Eps, JL; Scherba, JC; Haddix, S; Livingston, M; Bryan, NS; Cantu, C; Valson, C; Taraballi, F; Kaplan, LJ; Olsen, R ...
Published in: Surg Infect (Larchmt)
November 2021

Background: Infected hernia mesh is a cause of post-operative morbidity. Nitric oxide (NO) plays a key role in the endogenous immune response to infection. We sought to study the efficacy of a NO-releasing mesh against methicillin-resistant Staphylococcus aureus (MRSA). We hypothesized that a NO-releasing polyester mesh would decrease MRSA colonization and proliferation. Materials and Methods: A composite polyester mesh functionalized with N-diazeniumdiolate silica nanoparticles was synthesized and characterized. N-diazeniumdiolate silica parietex composite (NOSi) was inoculated with 104,106, or 108 colony forming units (CFUs) of MRSA and a dose response was quantified in a soy tryptic broth assay. Utilizing a rat model of contaminated hernia repair, implanted mesh was inoculated with MRSA, recovered, and CFUs were quantified. Clinical metrics of erythema, mesh contracture, and adhesion severity were then characterized. Results: Methicillin-resistant Staphylococcus aureus CFUs demonstrated a dose-dependent response to NOSi in vitro. In vivo, quantified CFUs showed a dose-dependent response to NOSi-PCO. Treated rats had fewer severe adhesions, less erythema, and reduced mesh contracture. Conclusions: We demonstrate the efficacy of a NO-releasing mesh to treat MRSA in vitro and in vivo. Creation of a novel class of antimicrobial prosthetics offers new strategies for reconstructing contaminated abdominal wall defects and other procedures that benefit from deploying synthetic prostheses in contaminated environments.

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Published In

Surg Infect (Larchmt)

DOI

EISSN

1557-8674

Publication Date

November 2021

Volume

22

Issue

9

Start / End Page

910 / 922

Location

United States

Related Subject Headings

  • Surgical Mesh
  • Surgery
  • Staphylococcal Infections
  • Silicon Dioxide
  • Rats
  • Polyesters
  • Nitric Oxide
  • Nanoparticles
  • Methicillin-Resistant Staphylococcus aureus
  • Animals
 

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Fernandez-Moure, J. S., Van Eps, J. L., Scherba, J. C., Haddix, S., Livingston, M., Bryan, N. S., … Tasciotti, E. (2021). Polyester Mesh Functionalization with Nitric Oxide-Releasing Silica Nanoparticles Reduces Early Methicillin-Resistant Staphylococcus aureus Contamination. Surg Infect (Larchmt), 22(9), 910–922. https://doi.org/10.1089/sur.2020.288
Fernandez-Moure, Joseph S., Jeffrey L. Van Eps, Jacob C. Scherba, Seth Haddix, Megan Livingston, Nathan S. Bryan, Concepcion Cantu, et al. “Polyester Mesh Functionalization with Nitric Oxide-Releasing Silica Nanoparticles Reduces Early Methicillin-Resistant Staphylococcus aureus Contamination.Surg Infect (Larchmt) 22, no. 9 (November 2021): 910–22. https://doi.org/10.1089/sur.2020.288.
Fernandez-Moure JS, Van Eps JL, Scherba JC, Haddix S, Livingston M, Bryan NS, et al. Polyester Mesh Functionalization with Nitric Oxide-Releasing Silica Nanoparticles Reduces Early Methicillin-Resistant Staphylococcus aureus Contamination. Surg Infect (Larchmt). 2021 Nov;22(9):910–22.
Fernandez-Moure, Joseph S., et al. “Polyester Mesh Functionalization with Nitric Oxide-Releasing Silica Nanoparticles Reduces Early Methicillin-Resistant Staphylococcus aureus Contamination.Surg Infect (Larchmt), vol. 22, no. 9, Nov. 2021, pp. 910–22. Pubmed, doi:10.1089/sur.2020.288.
Fernandez-Moure JS, Van Eps JL, Scherba JC, Haddix S, Livingston M, Bryan NS, Cantu C, Valson C, Taraballi F, Kaplan LJ, Olsen R, Tasciotti E. Polyester Mesh Functionalization with Nitric Oxide-Releasing Silica Nanoparticles Reduces Early Methicillin-Resistant Staphylococcus aureus Contamination. Surg Infect (Larchmt). 2021 Nov;22(9):910–922.
Journal cover image

Published In

Surg Infect (Larchmt)

DOI

EISSN

1557-8674

Publication Date

November 2021

Volume

22

Issue

9

Start / End Page

910 / 922

Location

United States

Related Subject Headings

  • Surgical Mesh
  • Surgery
  • Staphylococcal Infections
  • Silicon Dioxide
  • Rats
  • Polyesters
  • Nitric Oxide
  • Nanoparticles
  • Methicillin-Resistant Staphylococcus aureus
  • Animals