Biofabrication of tissue engineering vascular systems.

Journal Article (Review;Journal Article)

Cardiovascular disease (CVD) is the leading cause of death among persons aged 65 and older in the United States and many other developed countries. Tissue engineered vascular systems (TEVS) can serve as grafts for CVD treatment and be used as in vitro model systems to examine the role of various genetic factors during the CVD progressions. Current focus in the field is to fabricate TEVS that more closely resembles the mechanical properties and extracellular matrix environment of native vessels, which depends heavily on the advance in biofabrication techniques and discovery of novel biomaterials. In this review, we outline the mechanical and biological design requirements of TEVS and explore the history and recent advances in biofabrication methods and biomaterials for tissue engineered blood vessels and microvascular systems with special focus on in vitro applications. In vitro applications of TEVS for disease modeling are discussed.

Full Text

Duke Authors

Cited Authors

  • Zhang, Q; Bosch-Rué, È; Pérez, RA; Truskey, GA

Published Date

  • June 2021

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 021507 -

PubMed ID

  • 33981941

Pubmed Central ID

  • PMC8106537

Electronic International Standard Serial Number (EISSN)

  • 2473-2877

International Standard Serial Number (ISSN)

  • 2473-2877

Digital Object Identifier (DOI)

  • 10.1063/5.0039628

Language

  • eng