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Metabolomics in cancer research and emerging applications in clinical oncology.

Publication ,  Journal Article
Schmidt, DR; Patel, R; Kirsch, DG; Lewis, CA; Vander Heiden, MG; Locasale, JW
Published in: CA Cancer J Clin
July 2021

Cancer has myriad effects on metabolism that include both rewiring of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment, and changes in normal tissue metabolism. With the recognition that fluorodeoxyglucose-positron emission tomography imaging is an important tool for the management of many cancers, other metabolites in biological samples have been in the spotlight for cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecule metabolites that like other -omics technologies can provide critical information about the cancer state that are otherwise not apparent. Here, the authors review how cancer and cancer therapies interact with metabolism at the cellular and systemic levels. An overview of metabolomics is provided with a focus on currently available technologies and how they have been applied in the clinical and translational research setting. The authors also discuss how metabolomics could be further leveraged in the future to improve the management of patients with cancer.

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Published In

CA Cancer J Clin

DOI

EISSN

1542-4863

Publication Date

July 2021

Volume

71

Issue

4

Start / End Page

333 / 358

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Molecular Targeted Therapy
  • Metabolomics
  • Medical Oncology
  • Humans
  • Biomedical Research
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Schmidt, D. R., Patel, R., Kirsch, D. G., Lewis, C. A., Vander Heiden, M. G., & Locasale, J. W. (2021). Metabolomics in cancer research and emerging applications in clinical oncology. CA Cancer J Clin, 71(4), 333–358. https://doi.org/10.3322/caac.21670
Schmidt, Daniel R., Rutulkumar Patel, David G. Kirsch, Caroline A. Lewis, Matthew G. Vander Heiden, and Jason W. Locasale. “Metabolomics in cancer research and emerging applications in clinical oncology.CA Cancer J Clin 71, no. 4 (July 2021): 333–58. https://doi.org/10.3322/caac.21670.
Schmidt DR, Patel R, Kirsch DG, Lewis CA, Vander Heiden MG, Locasale JW. Metabolomics in cancer research and emerging applications in clinical oncology. CA Cancer J Clin. 2021 Jul;71(4):333–58.
Schmidt, Daniel R., et al. “Metabolomics in cancer research and emerging applications in clinical oncology.CA Cancer J Clin, vol. 71, no. 4, July 2021, pp. 333–58. Pubmed, doi:10.3322/caac.21670.
Schmidt DR, Patel R, Kirsch DG, Lewis CA, Vander Heiden MG, Locasale JW. Metabolomics in cancer research and emerging applications in clinical oncology. CA Cancer J Clin. 2021 Jul;71(4):333–358.
Journal cover image

Published In

CA Cancer J Clin

DOI

EISSN

1542-4863

Publication Date

July 2021

Volume

71

Issue

4

Start / End Page

333 / 358

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Molecular Targeted Therapy
  • Metabolomics
  • Medical Oncology
  • Humans
  • Biomedical Research
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences