Metabolomics in cancer research and emerging applications in clinical oncology.

Journal Article (Journal Article;Review)

Cancer has myriad effects on metabolism that include both rewiring of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment, and changes in normal tissue metabolism. With the recognition that fluorodeoxyglucose-positron emission tomography imaging is an important tool for the management of many cancers, other metabolites in biological samples have been in the spotlight for cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecule metabolites that like other -omics technologies can provide critical information about the cancer state that are otherwise not apparent. Here, the authors review how cancer and cancer therapies interact with metabolism at the cellular and systemic levels. An overview of metabolomics is provided with a focus on currently available technologies and how they have been applied in the clinical and translational research setting. The authors also discuss how metabolomics could be further leveraged in the future to improve the management of patients with cancer.

Full Text

Duke Authors

Cited Authors

  • Schmidt, DR; Patel, R; Kirsch, DG; Lewis, CA; Vander Heiden, MG; Locasale, JW

Published Date

  • July 2021

Published In

Volume / Issue

  • 71 / 4

Start / End Page

  • 333 - 358

PubMed ID

  • 33982817

Pubmed Central ID

  • PMC8298088

Electronic International Standard Serial Number (EISSN)

  • 1542-4863

Digital Object Identifier (DOI)

  • 10.3322/caac.21670

Language

  • eng

Conference Location

  • United States