Longitudinal visual field variability and the ability to detect glaucoma progression in black and white individuals.

Journal Article (Journal Article)

To investigate racial differences in the variability of longitudinal visual field testing in a 'real-world' clinical population, evaluate how these differences are influenced by socioeconomic status, and estimate the impact of differences in variability on the time to detect visual field progression. This retrospective observational cohort study used data from 1103 eyes from 751 White individuals and 428 eyes from 317 black individuals. Linear regression was performed on the standard automated perimetry mean deviation values for each eye over time. The SD of the residuals from the trend lines was calculated and used as a measure of variability for each eye. The association of race with the SD of the residuals was evaluated using a multivariable generalised estimating equation model with an interaction between race and zip code income. Computer simulations were used to estimate the time to detect visual field progression in the two racial groups. Black patients had larger visual field variability over time compared with white patients, even when adjusting for zip code level socioeconomic variables (SD of residuals for Black patients=1.53 dB (95% CI 1.43 to 1.64); for white patients=1.26 dB (95% CI 1.14 to 1.22); mean difference: 0.28 (95% CI 0.15 to 0.41); p<0.001). The difference in visual field variability between black and white patients was greater at lower levels of income and led to a delay in detection of glaucoma progression. Black patients had larger visual field variability compared with white patients. This relationship was strongly influenced by socioeconomic status and may partially explain racial disparities in glaucoma outcomes.

Full Text

Duke Authors

Cited Authors

  • Stagg, B; Mariottoni, EB; Berchuck, S; Jammal, A; Elam, AR; Hess, R; Kawamoto, K; Haaland, B; Medeiros, FA

Published Date

  • May 13, 2021

Published In

Start / End Page

  • bjophthalmol-2020-318104 -

PubMed ID

  • 33985963

Pubmed Central ID

  • PMC8589883

Electronic International Standard Serial Number (EISSN)

  • 1468-2079

International Standard Serial Number (ISSN)

  • 0007-1161

Digital Object Identifier (DOI)

  • 10.1136/bjophthalmol-2020-318104

Language

  • eng