Leukaemia: a model metastatic disease.

Journal Article (Journal Article;Review)

In contrast to solid cancers, which often require genetic modifications and complex cellular reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the innate ability for migration and invasion. Dedifferentiated, malignant leukocytes retain the benign leukocytes' capacity for cell motility and survival in the circulation, while acquiring the potential for rapid and uncontrolled cell division. For these reasons, leukaemias, although not traditionally considered as metastatic diseases, are in fact models of highly efficient metastatic spread. Accordingly, they are often aggressive and challenging diseases to treat. In this Perspective, we discuss the key molecular processes that facilitate metastasis in a variety of leukaemic subtypes, the clinical significance of leukaemic invasion into specific tissues and the current pipeline of treatments targeting leukaemia metastasis.

Full Text

Duke Authors

Cited Authors

  • Whiteley, AE; Price, TT; Cantelli, G; Sipkins, DA

Published Date

  • July 2021

Published In

Volume / Issue

  • 21 / 7

Start / End Page

  • 461 - 475

PubMed ID

  • 33953370

Pubmed Central ID

  • PMC8722462

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

Digital Object Identifier (DOI)

  • 10.1038/s41568-021-00355-z

Language

  • eng

Conference Location

  • England