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Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study.

Publication ,  Journal Article
Evans, DR; Lazarides, AL; Cullen, MM; Visgauss, JD; Somarelli, JA; Blazer, DG; Brigman, BE; Eward, WC
Published in: Ann Surg Oncol
November 2021

BACKGROUND: There are limited data to inform risk of readmission and short-term mortality in musculoskeletal oncology. The goal of this study was to identify factors independently associated with 30-day readmission and 90-day mortality following surgical resection of osteosarcoma. METHODS: We retrospectively reviewed patients (n = 5293) following surgical resection of primary osteosarcoma in the National Cancer Database (2004-2015). Univariate and multivariate methods were used to correlate variables with readmission and short-term mortality. RESULTS: Of 210 readmissions (3.97%), risk factors independently associated with unplanned 30-day readmission included comorbidity burden (odds ratio [OR] 2.4, p = 0.042), Medicare insurance (OR 1.9, p = 0.021), and axial skeleton location (OR 1.5, p = 0.029). A total of 91 patients died within 90 days of their surgery (1.84%). Risk factors independently associated with mortality included age (hazard ratio 1.1, p < 0.001), increasing comorbidity burden (OR 6.6, p = 0.001), higher grade (OR 1.7, p = 0.007), increasing tumor size (OR 2.2, p = 0.03), metastatic disease at presentation (OR 8.5, p < 0.001), and amputation (OR 2.0, p = 0.04). Chemotherapy was associated with a decreased risk of short-term mortality (p < 0.001). CONCLUSIONS: Several trends were clear: insurance status, tumor location and comorbidity burden were independently associated with readmission rates, while age, amputation, grade, tumor size, metastatic disease, and comorbidity burden were independently associated with short-term mortality.

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Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

November 2021

Volume

28

Issue

12

Start / End Page

7961 / 7972

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Retrospective Studies
  • Postoperative Complications
  • Patient Readmission
  • Osteosarcoma
  • Oncology & Carcinogenesis
  • Medicare
  • Humans
  • Databases, Factual
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Evans, D. R., Lazarides, A. L., Cullen, M. M., Visgauss, J. D., Somarelli, J. A., Blazer, D. G., … Eward, W. C. (2021). Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study. Ann Surg Oncol, 28(12), 7961–7972. https://doi.org/10.1245/s10434-021-10099-7
Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study.Ann Surg Oncol 28, no. 12 (November 2021): 7961–72. https://doi.org/10.1245/s10434-021-10099-7.
Evans DR, Lazarides AL, Cullen MM, Visgauss JD, Somarelli JA, Blazer DG, et al. Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study. Ann Surg Oncol. 2021 Nov;28(12):7961–72.
Evans, Daniel R., et al. “Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study.Ann Surg Oncol, vol. 28, no. 12, Nov. 2021, pp. 7961–72. Pubmed, doi:10.1245/s10434-021-10099-7.
Evans DR, Lazarides AL, Cullen MM, Visgauss JD, Somarelli JA, Blazer DG, Brigman BE, Eward WC. Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study. Ann Surg Oncol. 2021 Nov;28(12):7961–7972.
Journal cover image

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

November 2021

Volume

28

Issue

12

Start / End Page

7961 / 7972

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Retrospective Studies
  • Postoperative Complications
  • Patient Readmission
  • Osteosarcoma
  • Oncology & Carcinogenesis
  • Medicare
  • Humans
  • Databases, Factual