The Role of Surgical Lung Biopsy in the Diagnosis of Fibrotic Interstitial Lung Disease: Perspective from the Pulmonary Fibrosis Foundation.

Journal Article (Journal Article;Review)

Diagnosis of interstitial lung disease (ILD) requires a multidisciplinary discussion approach that includes clinicians, radiologists, and pathologists. Surgical lung biopsy (SLB) is currently the recommended standard in obtaining pathologic specimens for patients with ILD requiring a tissue diagnosis. The increased diagnostic confidence and accuracy provided by microscopic pathology assessment of SLB specimens must be balanced with the associated risks in patients with ILD. This document was developed by the SLB Working Group of the Pulmonary Fibrosis Foundation, composed of a multidisciplinary group of ILD physicians, including pulmonologists, radiologists, pathologists, and thoracic surgeons. In this document, we present an up-to-date literature review of the indications, contraindications, risks, and alternatives to SLB in the diagnosis of fibrotic ILD; outline an integrated approach to the decision-making around SLB in the diagnosis of fibrotic ILD; and provide practical information to maximize the yield and safety of SLB.

Full Text

Duke Authors

Cited Authors

  • Hariri, LP; Roden, AC; Chung, JH; Danoff, SK; Gomez Manjarres, DC; Hartwig, M; Kheir, F; King, C; Kreider, M; Lynch, DA; Mooney, J; Muniappan, A; Myers, JL; Paoletti, L; Raj, R; Safdar, Z; Suliman, S; Thavarajah, K; Lederer, DJ; Rudell, FL; Bianchi, P; Shea, BS; Ley, B

Published Date

  • October 2021

Published In

Volume / Issue

  • 18 / 10

Start / End Page

  • 1601 - 1609

PubMed ID

  • 34004127

Electronic International Standard Serial Number (EISSN)

  • 2325-6621

Digital Object Identifier (DOI)

  • 10.1513/AnnalsATS.202009-1179FR


  • eng

Conference Location

  • United States