Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade.

Journal Article (Journal Article;Review)

The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that ABL inactivation impairs metastasis. The therapeutic effects of ABL inactivation are due in part to ABL-dependent regulation of diverse cellular processes related to the epithelial to mesenchymal transition and subsequent steps in the metastatic cascade. ABL kinases target multiple signaling pathways required for promoting one or more steps in the metastatic cascade. These findings highlight the potential utility of specific ABL kinase inhibitors as a novel treatment paradigm for patients with advanced metastatic disease. Video abstract.

Full Text

Duke Authors

Cited Authors

  • Luttman, JH; Colemon, A; Mayro, B; Pendergast, AM

Published Date

  • May 22, 2021

Published In

Volume / Issue

  • 19 / 1

Start / End Page

  • 59 -

PubMed ID

  • 34022881

Pubmed Central ID

  • PMC8140471

Electronic International Standard Serial Number (EISSN)

  • 1478-811X

Digital Object Identifier (DOI)

  • 10.1186/s12964-021-00739-6

Language

  • eng

Conference Location

  • England