Structural Aspects of Auxin Signaling.

Journal Article (Review;Journal Article)

Auxin signaling regulates growth and developmental processes in plants. The core of nuclear auxin signaling relies on just three components: TIR1/AFBs, Aux/IAAs, and ARFs. Each component is itself made up of several domains, all of which contribute to the regulation of auxin signaling. Studies of the structural aspects of these three core signaling components have deepened our understanding of auxin signaling dynamics and regulation. In addition to the structured domains of these components, intrinsically disordered regions within the proteins also impact auxin signaling outcomes. New research is beginning to uncover the role intrinsic disorder plays in auxin-regulated degradation and subcellular localization. Structured and intrinsically disordered domains affect auxin perception, protein degradation dynamics, and DNA binding. Taken together, subtle differences within the domains and motifs of each class of auxin signaling component affect signaling outcomes and specificity.

Full Text

Duke Authors

Cited Authors

  • Morffy, N; Strader, LC

Published Date

  • January 2022

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • a039883 -

PubMed ID

  • 34001533

Pubmed Central ID

  • PMC8725629

Electronic International Standard Serial Number (EISSN)

  • 1943-0264

International Standard Serial Number (ISSN)

  • 1943-0264

Digital Object Identifier (DOI)

  • 10.1101/cshperspect.a039883


  • eng