Growth Modulation by Stimulating the Growth Plate: A Pilot Study.

Journal Article (Journal Article)

This study investigates the ability of low-intensity pulsed ultrasound (LIPUS) or direct injection of recombinant growth hormone (rGH) to stimulate local growth of long bones. In a randomized controlled animal trial, healthy immature rabbits were allocated to 1 of the following 4 conditions: epiphyseal rGH periosteal injection, transdermal LIPUS, saline periosteal injection, or no treatment. New bone deposition was labeled with calcein at days 1 and 18, and microscopic measurements of growth were conducted by blinded observers. Statistically significant differences in growth were observed between the LIPUS and rGH stimulated legs compared with contralateral control legs (35% p = 0.04 and 41% p = 0.04, respectively); whereas no difference was observed between the 4 control groups (p = 0.37). There was no evidence of physeal bar formation, suggesting that direct injection of rGH and application of LIPUS around the distal femoral physis in rabbits may have a positive effect on microscopic growth without short-term adverse sequelae.

Full Text

Duke Authors

Cited Authors

  • Rickert, KD; Arrigoni, P; Guzel, CR; Barber, HF; Alman, BA; Lark, RK

Published Date

  • August 2021

Published In

Volume / Issue

  • 47 / 8

Start / End Page

  • 2339 - 2345

PubMed ID

  • 34016487

Electronic International Standard Serial Number (EISSN)

  • 1879-291X

Digital Object Identifier (DOI)

  • 10.1016/j.ultrasmedbio.2021.03.036


  • eng

Conference Location

  • England