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Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.

Publication ,  Conference
Babitt, JL; Eisenga, MF; Haase, VH; Kshirsagar, AV; Levin, A; Locatelli, F; Małyszko, J; Swinkels, DW; Tarng, D-C; Cheung, M; Jadoul, M ...
Published in: Kidney Int
June 2021

In chronic kidney disease, anemia and disordered iron homeostasis are prevalent and associated with significant adverse consequences. In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) issued an anemia guideline for managing the diagnosis, evaluation, and treatment of anemia in chronic kidney disease. Since then, new data have accrued from basic research, epidemiological studies, and randomized trials that warrant a re-examination of previous recommendations. Therefore, in 2019, KDIGO decided to convene 2 Controversies Conferences to review the latest evidence, explore new and ongoing controversies, assess change implications for the current KDIGO anemia guideline, and propose a research agenda. The first conference, described here, focused mainly on iron-related issues, including the contribution of disordered iron homeostasis to the anemia of chronic kidney disease, diagnostic challenges, available and emerging iron therapies, treatment targets, and patient outcomes. The second conference will discuss issues more specifically related to erythropoiesis-stimulating agents, including epoetins, and hypoxia-inducible factor-prolyl hydroxylase inhibitors. Here we provide a concise overview of the consensus points and controversies resulting from the first conference and prioritize key questions that need to be answered by future research.

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

June 2021

Volume

99

Issue

6

Start / End Page

1280 / 1295

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Prolyl-Hydroxylase Inhibitors
  • Iron
  • Humans
  • Hematinics
  • Anemia
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Babitt, J. L., Eisenga, M. F., Haase, V. H., Kshirsagar, A. V., Levin, A., Locatelli, F., … Conference Participants, . (2021). Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. In Kidney Int (Vol. 99, pp. 1280–1295). United States. https://doi.org/10.1016/j.kint.2021.03.020
Babitt, Jodie L., Michele F. Eisenga, Volker H. Haase, Abhijit V. Kshirsagar, Adeera Levin, Francesco Locatelli, Jolanta Małyszko, et al. “Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.” In Kidney Int, 99:1280–95, 2021. https://doi.org/10.1016/j.kint.2021.03.020.
Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, et al. Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. In: Kidney Int. 2021. p. 1280–95.
Babitt, Jodie L., et al. “Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.Kidney Int, vol. 99, no. 6, 2021, pp. 1280–95. Pubmed, doi:10.1016/j.kint.2021.03.020.
Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Małyszko J, Swinkels DW, Tarng D-C, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB, Conference Participants. Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. Kidney Int. 2021. p. 1280–1295.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

June 2021

Volume

99

Issue

6

Start / End Page

1280 / 1295

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Prolyl-Hydroxylase Inhibitors
  • Iron
  • Humans
  • Hematinics
  • Anemia
  • 3202 Clinical sciences
  • 1103 Clinical Sciences