Skip to main content
Journal cover image

CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.

Publication ,  Journal Article
Rakhra, K; Bachireddy, P; Zabuawala, T; Zeiser, R; Xu, L; Kopelman, A; Fan, AC; Yang, Q; Braunstein, L; Crosby, E; Ryeom, S; Felsher, DW
Published in: Cancer Cell
November 16, 2010

Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the initiation and restraint of tumorigenesis, but their role in oncogene inactivation-mediated tumor regression is unclear. Here, we show that an intact immune system, specifically CD4(+) T cells, is required for the induction of cellular senescence, shutdown of angiogenesis, and chemokine expression resulting in sustained tumor regression upon inactivation of the MYC or BCR-ABL oncogenes in mouse models of T cell acute lymphoblastic lymphoma and pro-B cell leukemia, respectively. Moreover, immune effectors knocked out for thrombospondins failed to induce sustained tumor regression. Hence, CD4(+) T cells are required for the remodeling of the tumor microenvironment through the expression of chemokines, such as thrombospondins, in order to elicit oncogene addiction.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

November 16, 2010

Volume

18

Issue

5

Start / End Page

485 / 498

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Thrombospondin 1
  • Remission Induction
  • Proto-Oncogene Proteins c-myc
  • Oncology & Carcinogenesis
  • Oncogenes
  • Neovascularization, Pathologic
  • Neoplasms
  • Mice, Transgenic
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rakhra, K., Bachireddy, P., Zabuawala, T., Zeiser, R., Xu, L., Kopelman, A., … Felsher, D. W. (2010). CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell, 18(5), 485–498. https://doi.org/10.1016/j.ccr.2010.10.002
Rakhra, Kavya, Pavan Bachireddy, Tahera Zabuawala, Robert Zeiser, Liwen Xu, Andrew Kopelman, Alice C. Fan, et al. “CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.Cancer Cell 18, no. 5 (November 16, 2010): 485–98. https://doi.org/10.1016/j.ccr.2010.10.002.
Rakhra K, Bachireddy P, Zabuawala T, Zeiser R, Xu L, Kopelman A, et al. CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell. 2010 Nov 16;18(5):485–98.
Rakhra, Kavya, et al. “CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.Cancer Cell, vol. 18, no. 5, Nov. 2010, pp. 485–98. Pubmed, doi:10.1016/j.ccr.2010.10.002.
Rakhra K, Bachireddy P, Zabuawala T, Zeiser R, Xu L, Kopelman A, Fan AC, Yang Q, Braunstein L, Crosby E, Ryeom S, Felsher DW. CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell. 2010 Nov 16;18(5):485–498.
Journal cover image

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

November 16, 2010

Volume

18

Issue

5

Start / End Page

485 / 498

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Thrombospondin 1
  • Remission Induction
  • Proto-Oncogene Proteins c-myc
  • Oncology & Carcinogenesis
  • Oncogenes
  • Neovascularization, Pathologic
  • Neoplasms
  • Mice, Transgenic
  • Mice