Skip to main content

Multisite multivendor validation of a quantitative MRI and CT compatible fat phantom.

Publication ,  Journal Article
Zhao, R; Hernando, D; Harris, DT; Hinshaw, LA; Li, K; Ananthakrishnan, L; Bashir, MR; Duan, X; Ghasabeh, MA; Kamel, IR; Lowry, C; Mahesh, M ...
Published in: Med Phys
August 2021

PURPOSE: Chemical shift-encoded magnetic resonance imaging enables accurate quantification of liver fat content though estimation of proton density fat-fraction (PDFF). Computed tomography (CT) is capable of quantifying fat, based on decreased attenuation with increased fat concentration. Current quantitative fat phantoms do not accurately mimic the CT number of human liver. The purpose of this work was to develop and validate an optimized phantom that simultaneously mimics the MRI and CT signals of fatty liver. METHODS: An agar-based phantom containing 12 vials doped with iodinated contrast, and with a granular range of fat fractions was designed and constructed within a novel CT and MR compatible spherical housing design. A four-site, three-vendor validation study was performed. MRI (1.5T and 3T) and CT images were obtained using each vendor's PDFF and CT reconstruction, respectively. An ROI centered in each vial was placed to measure MRI-PDFF (%) and CT number (HU). Mixed-effects model, linear regression, and Bland-Altman analysis were used for statistical analysis. RESULTS: MRI-PDFF agreed closely with nominal PDFF values across both field strengths and all MRI vendors. A linear relationship (slope = -0.54 ± 0.01%/HU, intercept = 37.15 ± 0.03%) with an R2 of 0.999 was observed between MRI-PDFF and CT number, replicating established in vivo signal behavior. Excellent test-retest repeatability across vendors (MRI: mean = -0.04%, 95% limits of agreement = [-0.24%, 0.16%]; CT: mean = 0.16 HU, 95% limits of agreement = [-0.15HU, 0.47HU]) and good reproducibility using GE scanners (MRI: mean = -0.21%, 95% limits of agreement = [-1.47%, 1.06%]; CT: mean = -0.18HU, 95% limits of agreement = [-1.96HU, 1.6HU]) were demonstrated. CONCLUSIONS: The proposed fat phantom successfully mimicked quantitative liver signal for both MRI and CT. The proposed fat phantom in this study may facilitate broader application and harmonization of liver fat quantification techniques using MRI and CT across institutions, vendors and imaging platforms.

Duke Scholars

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

August 2021

Volume

48

Issue

8

Start / End Page

4375 / 4386

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Reproducibility of Results
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Liver
  • Humans
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhao, R., Hernando, D., Harris, D. T., Hinshaw, L. A., Li, K., Ananthakrishnan, L., … Reeder, S. B. (2021). Multisite multivendor validation of a quantitative MRI and CT compatible fat phantom. Med Phys, 48(8), 4375–4386. https://doi.org/10.1002/mp.15038
Zhao, Ruiyang, Diego Hernando, David T. Harris, Louis A. Hinshaw, Ke Li, Lakshmi Ananthakrishnan, Mustafa R. Bashir, et al. “Multisite multivendor validation of a quantitative MRI and CT compatible fat phantom.Med Phys 48, no. 8 (August 2021): 4375–86. https://doi.org/10.1002/mp.15038.
Zhao R, Hernando D, Harris DT, Hinshaw LA, Li K, Ananthakrishnan L, et al. Multisite multivendor validation of a quantitative MRI and CT compatible fat phantom. Med Phys. 2021 Aug;48(8):4375–86.
Zhao, Ruiyang, et al. “Multisite multivendor validation of a quantitative MRI and CT compatible fat phantom.Med Phys, vol. 48, no. 8, Aug. 2021, pp. 4375–86. Pubmed, doi:10.1002/mp.15038.
Zhao R, Hernando D, Harris DT, Hinshaw LA, Li K, Ananthakrishnan L, Bashir MR, Duan X, Ghasabeh MA, Kamel IR, Lowry C, Mahesh M, Marin D, Miller J, Pickhardt PJ, Shaffer J, Yokoo T, Brittain JH, Reeder SB. Multisite multivendor validation of a quantitative MRI and CT compatible fat phantom. Med Phys. 2021 Aug;48(8):4375–4386.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

August 2021

Volume

48

Issue

8

Start / End Page

4375 / 4386

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Reproducibility of Results
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
  • Liver
  • Humans
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering