Recumbent Total Skin Electron Beam Therapy.

Journal Article (Journal Article)

PURPOSE: Our purpose was to describe preliminary dosimetric and clinical results of a recumbent total skin electron beam therapy (TSEBT) technique and compare this to a conventional standing TSEBT technique. METHODS AND MATERIALS: A customized treatment platform with recessed side wheels was constructed and commissioned for patients to be treated in a recumbent position. Dosimetric and clinical information was collected for patients treated with this new recumbent technique in addition to that of a cohort of patients treated contemporaneously using the conventional standing method. Dose delivery and clinical outcomes were compared for patients treated with the recumbent and standing techniques. RESULTS: Between 2017 and 2019, 27 patients were treated with TSEBT with the recumbent (n = 13) or conventional standing technique (n = 14) at our institution. Measured dose at 15 body sites could be directly compared. Of these, 10 showed no significant difference between the two techniques while five sites showed significant differences in median measured dose, including the top of left shoulder, right biceps, bend of left elbow, upper back, and medial right thigh (P < .003). Measured dose was significantly higher with the standing technique at these sites with the exception of the upper back. Rates of complete response (25% vs 23%), partial response (50% vs 69%), and stable disease (17% vs 8%) were similar between the standing and recumbent cohorts, respectively (P = .78). CONCLUSIONS: We have developed, commissioned, and implemented a floor-based, recumbent technique that allows for treatment of patients who would otherwise not be eligible for TSEBT. Dosimetric and clinical measurements suggest that this technique is a viable alternative to the standing method.

Full Text

Duke Authors

Cited Authors

  • Ackerson, BG; Wu, Q; Craciunescu, O; Oyekunle, T; Niedzwiecki, D; Gupton, J; Laug, P; Brumfield, K; Crain, E; Champ, CE; Kelsey, CR

Published Date

  • 2021

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 100698 -

PubMed ID

  • 34409205

Pubmed Central ID

  • PMC8361039

International Standard Serial Number (ISSN)

  • 2452-1094

Digital Object Identifier (DOI)

  • 10.1016/j.adro.2021.100698

Language

  • eng

Conference Location

  • United States