Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study.

Journal Article (Journal Article)

We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc analysis of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 weeks of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatography/mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet.

Full Text

Duke Authors

Cited Authors

  • Pourafshar, S; Nicchitta, M; Tyson, CC; Svetkey, LP; Corcoran, DL; Bain, JR; Muehlbauer, MJ; Ilkayeva, O; O'Connell, TM; Lin, P-H; Scialla, JJ

Published Date

  • May 22, 2021

Published In

Volume / Issue

  • 13 / 6

PubMed ID

  • 34067295

Pubmed Central ID

  • PMC8224662

Electronic International Standard Serial Number (EISSN)

  • 2072-6643

Digital Object Identifier (DOI)

  • 10.3390/nu13061768


  • eng

Conference Location

  • Switzerland