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Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.

Publication ,  Journal Article
Herati, RS; Silva, LV; Vella, LA; Muselman, A; Alanio, C; Bengsch, B; Kurupati, RK; Kannan, S; Manne, S; Kossenkov, AV; Canaday, DH; Doyle, SA ...
Published in: Cell Rep Med
May 18, 2021

Humoral immune responses are dysregulated with aging, but the cellular and molecular pathways involved remain incompletely understood. In particular, little is known about the effects of aging on T follicular helper (Tfh) CD4 cells, the key cells that provide help to B cells for effective humoral immunity. We performed transcriptional profiling and cellular analysis on circulating Tfh before and after influenza vaccination in young and elderly adults. First, whole-blood transcriptional profiling shows that ICOS+CD38+ cTfh following vaccination preferentially enriches in gene sets associated with youth versus aging compared to other circulating T cell types. Second, vaccine-induced ICOS+CD38+ cTfh from the elderly had increased the expression of genes associated with inflammation, including tumor necrosis factor-nuclear factor κB (TNF-NF-κB) pathway activation. Finally, vaccine-induced ICOS+CD38+ cTfh display strong enrichment for signatures of underlying age-associated biological changes. These data highlight the ability to use vaccine-induced cTfh as cellular "biosensors" of underlying inflammatory and/or overall immune health.

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Published In

Cell Rep Med

DOI

EISSN

2666-3791

Publication Date

May 18, 2021

Volume

2

Issue

5

Start / End Page

100262

Location

United States

Related Subject Headings

  • Vaccines
  • Vaccination
  • T-Lymphocytes, Helper-Inducer
  • Lymphocyte Count
  • Lymphocyte Activation
  • Inflammation
  • Inducible T-Cell Co-Stimulator Protein
  • Immunity, Humoral
  • Humans
  • B-Lymphocytes
 

Citation

APA
Chicago
ICMJE
MLA
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Herati, R. S., Silva, L. V., Vella, L. A., Muselman, A., Alanio, C., Bengsch, B., … Wherry, E. J. (2021). Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways. Cell Rep Med, 2(5), 100262. https://doi.org/10.1016/j.xcrm.2021.100262
Herati, Ramin Sedaghat, Luisa Victoria Silva, Laura A. Vella, Alexander Muselman, Cecile Alanio, Bertram Bengsch, Raj K. Kurupati, et al. “Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.Cell Rep Med 2, no. 5 (May 18, 2021): 100262. https://doi.org/10.1016/j.xcrm.2021.100262.
Herati RS, Silva LV, Vella LA, Muselman A, Alanio C, Bengsch B, et al. Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways. Cell Rep Med. 2021 May 18;2(5):100262.
Herati, Ramin Sedaghat, et al. “Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.Cell Rep Med, vol. 2, no. 5, May 2021, p. 100262. Pubmed, doi:10.1016/j.xcrm.2021.100262.
Herati RS, Silva LV, Vella LA, Muselman A, Alanio C, Bengsch B, Kurupati RK, Kannan S, Manne S, Kossenkov AV, Canaday DH, Doyle SA, Ertl HCJ, Schmader KE, Wherry EJ. Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways. Cell Rep Med. 2021 May 18;2(5):100262.

Published In

Cell Rep Med

DOI

EISSN

2666-3791

Publication Date

May 18, 2021

Volume

2

Issue

5

Start / End Page

100262

Location

United States

Related Subject Headings

  • Vaccines
  • Vaccination
  • T-Lymphocytes, Helper-Inducer
  • Lymphocyte Count
  • Lymphocyte Activation
  • Inflammation
  • Inducible T-Cell Co-Stimulator Protein
  • Immunity, Humoral
  • Humans
  • B-Lymphocytes