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Trajectories of fatigue in a population-based sample of older adult breast, prostate, and colorectal cancer survivors: an analysis using the SEER-MHOS data resource.

Publication ,  Journal Article
Byrne, M; Leiser, J; Mitchell, SA; Kent, EE; Siembida, EJ; Somers, T; Arem, H
Published in: Support Care Cancer
December 2021

PURPOSE: Fatigue is one of the most common and distressing symptoms experienced by cancer survivors. Understanding fatigue trajectories from pre- to post-diagnosis could inform fatigue prevention and management strategies. METHODS: We used the Surveillance, Epidemiology and End Results Medicare Health Outcomes Survey (SEER-MHOS) linked data resource to characterize fatigue trajectories and their predictors 1214 older adult survivors of breast, colorectal, or prostate cancer. Fatigue was measured prior to the cancer diagnosis (T0) and at two timepoints after diagnosis (T1: mean = 20 months and T2: mean = 39 months post-diagnosis). Latent growth curve modeling and mixed effects models for repeated measurements were used to investigate fatigue experiences before and after a cancer diagnosis. RESULTS: Overall, mean fatigue T-scores declined (T0 = 50, T1 = 46, and T2 = 45) indicating worsening fatigue over time. Four latent trajectory subgroups were identified: severe fatigue worsening over time (8.2% of sample), severe fatigue persisting over time (14.4%), no fatigue pre-diagnosis and mild fatigue post-diagnosis (44.4%), and not fatigued (33%). Age, cancer stage, comorbidities, and depressed mood predicted membership in the two trajectory groups experiencing severe fatigue that persisted or that worsened post-diagnosis. Older age, advanced cancer stage at diagnosis, and depressed mood were significantly associated with worsening fatigue from T1 to T2 (all p < 0.0001). CONCLUSIONS: Evaluating cancer patients for depressive symptoms and considering prior fatigue levels, age, comorbid conditions, and cancer stage may help providers anticipate fatigue trajectories and implement pre-emptive strategies to lessen fatigue impact.

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Published In

Support Care Cancer

DOI

EISSN

1433-7339

Publication Date

December 2021

Volume

29

Issue

12

Start / End Page

7393 / 7402

Location

Germany

Related Subject Headings

  • United States
  • Survivors
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Medicare
  • Male
  • Humans
  • Fatigue
  • Colorectal Neoplasms
  • Cancer Survivors
 

Citation

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ICMJE
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Byrne, M., Leiser, J., Mitchell, S. A., Kent, E. E., Siembida, E. J., Somers, T., & Arem, H. (2021). Trajectories of fatigue in a population-based sample of older adult breast, prostate, and colorectal cancer survivors: an analysis using the SEER-MHOS data resource. Support Care Cancer, 29(12), 7393–7402. https://doi.org/10.1007/s00520-021-06267-w
Byrne, Morgan, Jaclyn Leiser, Sandra A. Mitchell, Erin E. Kent, Elizabeth J. Siembida, Tamara Somers, and Hannah Arem. “Trajectories of fatigue in a population-based sample of older adult breast, prostate, and colorectal cancer survivors: an analysis using the SEER-MHOS data resource.Support Care Cancer 29, no. 12 (December 2021): 7393–7402. https://doi.org/10.1007/s00520-021-06267-w.
Byrne M, Leiser J, Mitchell SA, Kent EE, Siembida EJ, Somers T, et al. Trajectories of fatigue in a population-based sample of older adult breast, prostate, and colorectal cancer survivors: an analysis using the SEER-MHOS data resource. Support Care Cancer. 2021 Dec;29(12):7393–402.
Byrne, Morgan, et al. “Trajectories of fatigue in a population-based sample of older adult breast, prostate, and colorectal cancer survivors: an analysis using the SEER-MHOS data resource.Support Care Cancer, vol. 29, no. 12, Dec. 2021, pp. 7393–402. Pubmed, doi:10.1007/s00520-021-06267-w.
Byrne M, Leiser J, Mitchell SA, Kent EE, Siembida EJ, Somers T, Arem H. Trajectories of fatigue in a population-based sample of older adult breast, prostate, and colorectal cancer survivors: an analysis using the SEER-MHOS data resource. Support Care Cancer. 2021 Dec;29(12):7393–7402.
Journal cover image

Published In

Support Care Cancer

DOI

EISSN

1433-7339

Publication Date

December 2021

Volume

29

Issue

12

Start / End Page

7393 / 7402

Location

Germany

Related Subject Headings

  • United States
  • Survivors
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Medicare
  • Male
  • Humans
  • Fatigue
  • Colorectal Neoplasms
  • Cancer Survivors