Spinal metastases 2021: a review of the current state of the art and future directions.

Journal Article (Journal Article;Review)

Spinal metastases are an increasing societal health burden secondary to improvements in systemic therapy. Estimates indicate that 100,000 or more people have symptomatic spine metastases requiring management. While open surgery and external beam radiotherapy have been the pillars of treatment, there is growing interest in more minimally invasive technologies (eg separation surgery) and non-operative interventions (eg percutaneous cementoplasty, stereotactic radiosurgery). The great expansion of these alternatives to open surgery and the prevalence of adjuvant therapeutic options means that treatment decision making is now complex and reliant upon multidisciplinary collaboration. To help facilitate construction of care plans that meet patient goals and expectations, clinical decision aids and prognostic scores have been developed. These have been shown to have superior predictive value relative to more classic prediction models and may become an increasingly important aspect of the clinical practice of spinal oncology. Here we overview current therapeutic advances in the management of spine metastases and highlight emerging areas for research. Given the rapid advancements in surgical technologies and adjuvants, the field is likely to undergo further transformative changes in the coming decade.

Full Text

Duke Authors

Cited Authors

  • Sciubba, DM; Pennington, Z; Colman, MW; Goodwin, CR; Laufer, I; Patt, JC; Redmond, KJ; Saylor, P; Shin, JH; Schwab, JH; Schoenfeld, AJ; NASS Spine Oncology Committee,

Published Date

  • September 2021

Published In

Volume / Issue

  • 21 / 9

Start / End Page

  • 1414 - 1429

PubMed ID

  • 33887454

Electronic International Standard Serial Number (EISSN)

  • 1878-1632

Digital Object Identifier (DOI)

  • 10.1016/j.spinee.2021.04.012


  • eng

Conference Location

  • United States