HIV-1 Envelope Conformation, Allostery, and Dynamics.

Journal Article (Journal Article;Review)

The HIV-1 envelope glycoprotein (Env) mediates host cell fusion and is the primary target for HIV-1 vaccine design. The Env undergoes a series of functionally important conformational rearrangements upon engagement of its host cell receptor, CD4. As the sole target for broadly neutralizing antibodies, our understanding of these transitions plays a critical role in vaccine immunogen design. Here, we review available experimental data interrogating the HIV-1 Env conformation and detail computational efforts aimed at delineating the series of conformational changes connecting these rearrangements. These studies have provided a structural mapping of prefusion closed, open, and transition intermediate structures, the allosteric elements controlling rearrangements, and state-to-state transition dynamics. The combination of these investigations and innovations in molecular modeling set the stage for advanced studies examining rearrangements at greater spatial and temporal resolution.

Full Text

Duke Authors

Cited Authors

  • Bennett, AL; Henderson, R

Published Date

  • May 7, 2021

Published In

Volume / Issue

  • 13 / 5

PubMed ID

  • 34067073

Pubmed Central ID

  • PMC8150877

Electronic International Standard Serial Number (EISSN)

  • 1999-4915

Digital Object Identifier (DOI)

  • 10.3390/v13050852

Language

  • eng

Conference Location

  • Switzerland