Sensing Inhalation Injury-Associated Changes in Airway Wall Compliance by Anatomic Optical Coherence Elastography.
Journal Article (Journal Article)
Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. Here, we demonstrate the use of a custom-built, endoscopic, anatomic optical coherence elastography (aOCE) system to measure airway wall compliance. The method was first validated using airway phantoms, then performed on ex vivo porcine tracheas under varying degrees of inhalation (steam) injury. A negative correlation between aOCE-derived compliance and severity of steam injuries is found, and spatially-resolved compliance maps reveal regional heterogeneity in airway properties.
Full Text
Duke Authors
Cited Authors
- Bu, R; Balakrishnan, S; Iftimia, N; Price, H; Zdanski, C; Mitran, S; Oldenburg, AL
Published Date
- August 2021
Published In
Volume / Issue
- 68 / 8
Start / End Page
- 2360 - 2367
PubMed ID
- 33175676
Pubmed Central ID
- PMC8110609
Electronic International Standard Serial Number (EISSN)
- 1558-2531
International Standard Serial Number (ISSN)
- 0018-9294
Digital Object Identifier (DOI)
- 10.1109/tbme.2020.3037288
Language
- eng