Sensing Inhalation Injury-Associated Changes in Airway Wall Compliance by Anatomic Optical Coherence Elastography.

Journal Article (Journal Article)

Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. Here, we demonstrate the use of a custom-built, endoscopic, anatomic optical coherence elastography (aOCE) system to measure airway wall compliance. The method was first validated using airway phantoms, then performed on ex vivo porcine tracheas under varying degrees of inhalation (steam) injury. A negative correlation between aOCE-derived compliance and severity of steam injuries is found, and spatially-resolved compliance maps reveal regional heterogeneity in airway properties.

Full Text

Duke Authors

Cited Authors

  • Bu, R; Balakrishnan, S; Iftimia, N; Price, H; Zdanski, C; Mitran, S; Oldenburg, AL

Published Date

  • August 2021

Published In

Volume / Issue

  • 68 / 8

Start / End Page

  • 2360 - 2367

PubMed ID

  • 33175676

Pubmed Central ID

  • PMC8110609

Electronic International Standard Serial Number (EISSN)

  • 1558-2531

International Standard Serial Number (ISSN)

  • 0018-9294

Digital Object Identifier (DOI)

  • 10.1109/tbme.2020.3037288


  • eng