Amblyopia is the most common cause of preventable visual impairment in childhood. A quality improvement project was conducted at a pediatric primary care clinic located in North Carolina over a 3-month period with the intent of improving the preschool vision screening process. Vision screening rates and time to complete a screening were compared between a Plusoptix S12C photoscreener (Plusoptix Inc.) and a traditional eye chart. Successful vision screening rates were significantly higher and time to perform a vision screening was significantly lower using the photoscreener compared with screening with an eye chart. A significant increase in knowledge among clinic staff after an in-person educational presentation on amblyopia was also noted.