Biosafety of low-intensity pulsed transcranial focused ultrasound brain stimulation - A human skull study

Conference Paper

Among a variety of existing modalities for noninvasive brain stimulation (NIBS), low-intensity pulsed transcranial focused ultrasound (tFUS) is a promising technique to precisely stimulate deep brain structures due to its high spatial specificity and superior penetration depth. While tFUS is gaining momentum as an emerging NIBS technique, an advisable biosafety-associated combination of sonication parameters including duty cycle and power input remains to be explored. In this study, biosafety of low-intensity pulsed tFUS using various sonication parameters was evaluated by measuring acoustic intensities and temperature variations across a piece of real human skull. The results showed that ISPTA above 480 mW/cm2 is likely to induce an excessive temperature rise for a sonication duration of 160 seconds. Also, the skull base effect and ultrasound transducer self-heating effect should be noted during the sonication. Based on the findings in this study, an initial biosafety guide was discussed for the future investigation of ultrasound-mediated NIBS.

Full Text

Duke Authors

Cited Authors

  • Chen, M; Peng, C; Kim, T; Chhatbar, PY; Muller, M; Feng, W; Jiang, X

Published Date

  • January 1, 2021

Published In

Volume / Issue

  • 11593 /

Electronic International Standard Serial Number (EISSN)

  • 1996-756X

International Standard Serial Number (ISSN)

  • 0277-786X

International Standard Book Number 13 (ISBN-13)

  • 9781510640153

Digital Object Identifier (DOI)

  • 10.1117/12.2582487

Citation Source

  • Scopus