Association of the CCR5 gene with juvenile idiopathic arthritis.

Journal Article (Journal Article;Multicenter Study)

The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction. A 32 base-pair insertion/deletion variant (CCR5Δ32) within the gene leads to a frame shift and a nonfunctional receptor. CCR5Δ32 has been investigated for its association with juvenile idiopathic arthritis (JIA), with conflicting results. The aim of this study was to investigate whether CCR5Δ32 is associated with JIA in an UK population. CCR5Δ32 was genotyped in JIA cases (n=1054) and healthy controls (n=3129) and genotype and allele frequencies were compared. A meta-analysis of our study combined with previously published studies was performed. CCR5Δ32 was significantly associated with protection from developing JIA, in this UK data set (P(trend)=0.006, odds ratio (OR) 0.79 95% confidence interval (95% CI): 0.66-0.94). The meta-analysis of all published case-control association studies confirmed the protective association with JIA (P=0.001 OR 0.82 95% CI: 0.73-0.93). CCR5Δ32 is a functional variant determining the number of receptors on the surface of T cells, and it is hypothesized that the level of CCR5 expression could influence the migration of proinflammatory T cells into the synovium and thus susceptibility to JIA.

Full Text

Duke Authors

Cited Authors

  • Hinks, A; Martin, P; Flynn, E; Eyre, S; Packham, J; Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR Study Group, ; Barton, A; Worthington, J; Thomson, W

Published Date

  • October 2010

Published In

Volume / Issue

  • 11 / 7

Start / End Page

  • 584 - 589

PubMed ID

  • 20463745

Pubmed Central ID

  • PMC2974598

Electronic International Standard Serial Number (EISSN)

  • 1476-5470

Digital Object Identifier (DOI)

  • 10.1038/gene.2010.25

Language

  • eng

Conference Location

  • England