Striving toward translation: strategies for reliable fMRI measurement.
fMRI has considerable potential as a translational tool for understanding risk, prioritizing interventions, and improving the treatment of brain disorders. However, recent studies have found that many of the most widely used fMRI measures have low reliability, undermining this potential. Here, we argue that many fMRI measures are unreliable because they were designed to identify group effects, not to precisely quantify individual differences. We then highlight four emerging strategies [extended aggregation, reliability modeling, multi-echo fMRI (ME-fMRI), and stimulus design] that build on established psychometric properties to generate more precise and reliable fMRI measures. By adopting such strategies to improve reliability, we are optimistic that fMRI can fulfill its potential as a clinical tool.
Duke Scholars
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Related Subject Headings
- Reproducibility of Results
- Magnetic Resonance Imaging
- Individuality
- Humans
- Experimental Psychology
- Brain Mapping
- Brain
- 5204 Cognitive and computational psychology
- 5203 Clinical and health psychology
- 17 Psychology and Cognitive Sciences
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Reproducibility of Results
- Magnetic Resonance Imaging
- Individuality
- Humans
- Experimental Psychology
- Brain Mapping
- Brain
- 5204 Cognitive and computational psychology
- 5203 Clinical and health psychology
- 17 Psychology and Cognitive Sciences