Satellite cell therapy - from mice to men.

Journal Article (Journal Article)

Satellite cells are rare mononuclear skeletal muscle-resident cells that are the chief contributors to regenerative myogenesis following muscle injury. Although first identified more than 50 years ago, it is only recently that the murine satellite cell has become molecularly defined with the ability to prospectively isolate these cells from their niche. Human satellite cells are considerably less well understood with relatively few studies having been performed on them. In this review, a critical evaluation of this literature is provided along with a discussion of the practical and methodological issues involved with research on human satellite cells. The therapeutic potential of these and other cells types is also discussed, and the various challenges that face satellite cell therapy are addressed.

Full Text

Duke Authors

Cited Authors

  • Bareja, A; Billin, AN

Published Date

  • January 31, 2013

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • 2 -

PubMed ID

  • 23369649

Pubmed Central ID

  • PMC3579761

International Standard Serial Number (ISSN)

  • 2044-5040

Digital Object Identifier (DOI)

  • 10.1186/2044-5040-3-2

Language

  • eng

Conference Location

  • England