Antigen-specific NK cell memory in rhesus macaques.

Journal Article (Journal Article)

Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from SHIV(SF162P3)-infected and SIV(mac251)-infected macaques specifically lysed Gag- and Env-pulsed dendritic cells in an NKG2-dependent fashion, in contrast to NK cells from uninfected macaques. Moreover, splenic and hepatic NK cells from Ad26-vaccinated macaques efficiently lysed antigen-matched but not antigen-mismatched targets 5 years after vaccination. These data demonstrate that robust, durable, antigen-specific NK cell memory can be induced in primates after both infection and vaccination, and this finding could be important for the development of vaccines against HIV-1 and other pathogens.

Full Text

Duke Authors

Cited Authors

  • Reeves, RK; Li, H; Jost, S; Blass, E; Li, H; Schafer, JL; Varner, V; Manickam, C; Eslamizar, L; Altfeld, M; von Andrian, UH; Barouch, DH

Published Date

  • September 2015

Published In

Volume / Issue

  • 16 / 9

Start / End Page

  • 927 - 932

PubMed ID

  • 26193080

Pubmed Central ID

  • PMC4545390

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

Digital Object Identifier (DOI)

  • 10.1038/ni.3227

Language

  • eng

Conference Location

  • United States