Skip to main content
Journal cover image

Broad spectrum antibacterial and antifungal polymeric paint materials: synthesis, structure-activity relationship, and membrane-active mode of action.

Publication ,  Journal Article
Hoque, J; Akkapeddi, P; Yadav, V; Manjunath, GB; Uppu, DSSM; Konai, MM; Yarlagadda, V; Sanyal, K; Haldar, J
Published in: ACS applied materials & interfaces
January 2015

Microbial attachment and subsequent colonization onto surfaces lead to the spread of deadly community-acquired and hospital-acquired (nosocomial) infections. Noncovalent immobilization of water insoluble and organo-soluble cationic polymers onto a surface is a facile approach to prevent microbial contamination. In the present study, we described the synthesis of water insoluble and organo-soluble polymeric materials and demonstrated their structure-activity relationship against various human pathogenic bacteria including drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and beta lactam-resistant Klebsiella pneumoniae as well as pathogenic fungi such as Candida spp. and Cryptococcus spp. The polymer coated surfaces completely inactivated both bacteria and fungi upon contact (5 log reduction with respect to control). Linear polymers were more active and found to have a higher killing rate than the branched polymers. The polymer coated surfaces also exhibited significant activity in various complex mammalian fluids such as serum, plasma, and blood and showed negligible hemolysis at an amount much higher than minimum inhibitory amounts (MIAs). These polymers were found to have excellent compatibility with other medically relevant polymers (polylactic acid, PLA) and commercial paint. The cationic hydrophobic polymer coatings disrupted the lipid membrane of both bacteria and fungi and thus showed a membrane-active mode of action. Further, bacteria did not develop resistance against these membrane-active polymers in sharp contrast to conventional antibiotics and lipopeptides, thus the polymers hold great promise to be used as coating materials for developing permanent antimicrobial paint.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

ACS applied materials & interfaces

DOI

EISSN

1944-8252

ISSN

1944-8244

Publication Date

January 2015

Volume

7

Issue

3

Start / End Page

1804 / 1815

Related Subject Headings

  • Polymers
  • Paint
  • Nanoscience & Nanotechnology
  • Humans
  • Cross Infection
  • Cell Membrane
  • Bacteria
  • Antifungal Agents
  • Anti-Bacterial Agents
  • 51 Physical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hoque, J., Akkapeddi, P., Yadav, V., Manjunath, G. B., Uppu, D. S. S. M., Konai, M. M., … Haldar, J. (2015). Broad spectrum antibacterial and antifungal polymeric paint materials: synthesis, structure-activity relationship, and membrane-active mode of action. ACS Applied Materials & Interfaces, 7(3), 1804–1815. https://doi.org/10.1021/am507482y
Hoque, Jiaul, Padma Akkapeddi, Vikas Yadav, Goutham B. Manjunath, Divakara S. S. M. Uppu, Mohini M. Konai, Venkateswarlu Yarlagadda, Kaustuv Sanyal, and Jayanta Haldar. “Broad spectrum antibacterial and antifungal polymeric paint materials: synthesis, structure-activity relationship, and membrane-active mode of action.ACS Applied Materials & Interfaces 7, no. 3 (January 2015): 1804–15. https://doi.org/10.1021/am507482y.
Hoque J, Akkapeddi P, Yadav V, Manjunath GB, Uppu DSSM, Konai MM, et al. Broad spectrum antibacterial and antifungal polymeric paint materials: synthesis, structure-activity relationship, and membrane-active mode of action. ACS applied materials & interfaces. 2015 Jan;7(3):1804–15.
Hoque, Jiaul, et al. “Broad spectrum antibacterial and antifungal polymeric paint materials: synthesis, structure-activity relationship, and membrane-active mode of action.ACS Applied Materials & Interfaces, vol. 7, no. 3, Jan. 2015, pp. 1804–15. Epmc, doi:10.1021/am507482y.
Hoque J, Akkapeddi P, Yadav V, Manjunath GB, Uppu DSSM, Konai MM, Yarlagadda V, Sanyal K, Haldar J. Broad spectrum antibacterial and antifungal polymeric paint materials: synthesis, structure-activity relationship, and membrane-active mode of action. ACS applied materials & interfaces. 2015 Jan;7(3):1804–1815.
Journal cover image

Published In

ACS applied materials & interfaces

DOI

EISSN

1944-8252

ISSN

1944-8244

Publication Date

January 2015

Volume

7

Issue

3

Start / End Page

1804 / 1815

Related Subject Headings

  • Polymers
  • Paint
  • Nanoscience & Nanotechnology
  • Humans
  • Cross Infection
  • Cell Membrane
  • Bacteria
  • Antifungal Agents
  • Anti-Bacterial Agents
  • 51 Physical sciences