Building and destroying synaptic bridges: How do Hevin/Sparcl1, SPARC, and MDGAs modify trans-synaptic neurexin-neuroligin interactions?

Journal Article (Journal Article)

Astrocyte-secreted Hevin induces synapse formation by bridging the trans-synaptic organizers, neuroligins and neurexins. In this issue of Structure, Fan et al. (2021) elucidate the structural basis of Hevin's interaction with these molecules and reveal the competitive interplay between Hevin, SPARC, and MDGAs.

Full Text

Duke Authors

Cited Authors

  • Ramirez, JJ; Bindu, DS; Eroglu, C

Published Date

  • July 1, 2021

Published In

Volume / Issue

  • 29 / 7

Start / End Page

  • 635 - 637

PubMed ID

  • 34214438

Electronic International Standard Serial Number (EISSN)

  • 1878-4186

Digital Object Identifier (DOI)

  • 10.1016/j.str.2021.06.011


  • eng

Conference Location

  • United States