Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.

Journal Article (Journal Article)

Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.

Full Text

Duke Authors

Cited Authors

  • Claassen, J; Akbari, Y; Alexander, S; Bader, MK; Bell, K; Bleck, TP; Boly, M; Brown, J; Chou, SH-Y; Diringer, MN; Edlow, BL; Foreman, B; Giacino, JT; Gosseries, O; Green, T; Greer, DM; Hanley, DF; Hartings, JA; Helbok, R; Hemphill, JC; Hinson, HE; Hirsch, K; Human, T; James, ML; Ko, N; Kondziella, D; Livesay, S; Madden, LK; Mainali, S; Mayer, SA; McCredie, V; McNett, MM; Meyfroidt, G; Monti, MM; Muehlschlegel, S; Murthy, S; Nyquist, P; Olson, DM; Provencio, JJ; Rosenthal, E; Sampaio Silva, G; Sarasso, S; Schiff, ND; Sharshar, T; Shutter, L; Stevens, RD; Vespa, P; Videtta, W; Wagner, A; Ziai, W; Whyte, J; Zink, E; Suarez, JI; Curing Coma Campaign,

Published Date

  • July 2021

Published In

Volume / Issue

  • 35 / Suppl 1

Start / End Page

  • 4 - 23

PubMed ID

  • 34236619

Pubmed Central ID

  • PMC8264966

Electronic International Standard Serial Number (EISSN)

  • 1556-0961

Digital Object Identifier (DOI)

  • 10.1007/s12028-021-01260-x


  • eng

Conference Location

  • United States