Guidelines for the Prevention and Management of Graft-versus-Host Disease after Cord Blood Transplantation.

Journal Article (Review)

The incidence of graft-versus-host disease (GVHD) after cord blood (CB) transplantation (CBT) is lower than expected given the marked degree of human leukocyte antigen (HLA)-mismatch of CB grafts. While the exact mechanism that underlies this biology remains unclear, it is hypothesized to be due to the low number of mostly immature T-cells infused as part of the graft1,2, and increased tolerance of CB-derived lymphocytes induced by the state of pregnancy. Nevertheless, acute GVHD (aGVHD) is a significant complication of CBT. In contrast, the incidence of chronic GVHD (cGVHD) following CBT is lower than what is observed following matched related or unrelated donor HSC transplantation (HSCT)3-6. This review outlines the guidelines for the prevention and management of acute and chronic GVHD following CBT.

Full Text

Duke Authors

Cited Authors

  • Ponce, DM; Politikos, I; Alousi, A; Carpenter, PA; Milano, F; MacMillan, ML; Barker, JN; Horwitz, ME; American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group,

Published Date

  • July 2021

Published In

  • Transplant Cell Ther

Volume / Issue

  • 27 / 7

Start / End Page

  • 540 - 544

PubMed ID

  • 34210500

Electronic International Standard Serial Number (EISSN)

  • 2666-6367

Digital Object Identifier (DOI)

  • 10.1016/j.jtct.2021.03.012

Language

  • eng

Conference Location

  • United States