Guidelines for the Prevention and Management of Graft-versus-Host Disease after Cord Blood Transplantation.
Journal Article (Review)
The incidence of graft-versus-host disease (GVHD) after cord blood (CB) transplantation (CBT) is lower than expected given the marked degree of human leukocyte antigen (HLA)-mismatch of CB grafts. While the exact mechanism that underlies this biology remains unclear, it is hypothesized to be due to the low number of mostly immature T-cells infused as part of the graft1,2, and increased tolerance of CB-derived lymphocytes induced by the state of pregnancy. Nevertheless, acute GVHD (aGVHD) is a significant complication of CBT. In contrast, the incidence of chronic GVHD (cGVHD) following CBT is lower than what is observed following matched related or unrelated donor HSC transplantation (HSCT)3-6. This review outlines the guidelines for the prevention and management of acute and chronic GVHD following CBT.
Full Text
Duke Authors
Cited Authors
- Ponce, DM; Politikos, I; Alousi, A; Carpenter, PA; Milano, F; MacMillan, ML; Barker, JN; Horwitz, ME; American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group,
Published Date
- July 2021
Published In
Volume / Issue
- 27 / 7
Start / End Page
- 540 - 544
PubMed ID
- 34210500
Electronic International Standard Serial Number (EISSN)
- 2666-6367
Digital Object Identifier (DOI)
- 10.1016/j.jtct.2021.03.012
Language
- eng
Conference Location
- United States