Short- and long-term opioid use in survivors of subarachnoid hemorrhage.

Journal Article (Journal Article)

OBJECTIVES: Opioids are frequently used for analgesia in patients with acute subarachnoid hemorrhage (SAH) due to a high prevalence of headache and neck pain. However, it is unclear if this practice may pose a risk for opioid dependence, as long-term opioid use in this population remains unknown. We sought to determine the prevalence of opioid use in SAH survivors, and to identify potential risk factors for opioid utilization. METHODS: We analyzed a cohort of consecutive patients admitted with non-traumatic and suspected aneurysmal SAH to an academic referral center. We included patients who survived hospitalization and excluded those who were not opioid-naïve. Potential risk factors for opioid prescription at discharge, 3 and 12 months post-discharge were assessed. RESULTS: Of 240 SAH patients who met our inclusion criteria (mean age 58.4 years [SD 14.8], 58% women), 233 (97%) received opioids during hospitalization and 152 (63%) received opioid prescription at discharge. Twenty-eight patients (12%) still continued to use opioids at 3 months post-discharge, and 13 patients (6%) at 12-month follow up. Although patients with poor Hunt and Hess grades (odds ratio 0.19, 95% CI 0.06-0.57) and those with intraventricular hemorrhage (odds ratio 0.38, 95% CI 0.18-0.87) were less likely to receive opioid prescriptions at discharge, we did not find significant differences between patients who had long-term opioid use and those who did not. CONCLUSION: Opioids are regularly used in both the acute SAH setting and immediately after discharge. A considerable number of patients also continue to use opioids in the long-term. Opioid-sparing pain control strategies should be explored in the future.

Full Text

Duke Authors

Cited Authors

  • Mahta, A; Anderson, MN; Azher, AI; Mahmoud, LN; Dakay, K; Abdulrazeq, H; Abud, A; Moody, S; Reznik, ME; Yaghi, S; Thompson, BB; Wendell, LC; Rao, SS; Potter, NS; Cutting, S; Mac Grory, B; Stretz, C; Doberstein, CE; Furie, KL

Published Date

  • August 2021

Published In

Volume / Issue

  • 207 /

Start / End Page

  • 106770 -

PubMed ID

  • 34182238

Electronic International Standard Serial Number (EISSN)

  • 1872-6968

Digital Object Identifier (DOI)

  • 10.1016/j.clineuro.2021.106770


  • eng

Conference Location

  • Netherlands