Reducing Overuse of Proton Pump Inhibitors for Stress Ulcer Prophylaxis and Nonvariceal Gastrointestinal Bleeding in the Hospital: A Narrative Review and Implementation Guide.

Journal Article (Journal Article;Review)

Proton pump inhibitors (PPIs) are among the most commonly used medications in the world; however, these drugs carry the risk of patient harm, including acute and chronic kidney disease, Clostridium difficile infection, hypomagnesemia, and fractures. In the hospital setting, PPIs are overused for stress ulcer prophylaxis and gastrointestinal bleeding, and PPI use often continues after discharge. Numerous multifaceted interventions have demonstrated safe and effective reduction of PPI use in the inpatient setting. This narrative review and the resulting implementation guide summarize published interventions to reduce inappropriate PPI use and provide a strategy for quality improvement teams.

Full Text

Duke Authors

Cited Authors

  • Clarke, K; Adler, N; Agrawal, D; Bhakta, D; Sata, SS; Singh, S; Gupta, A; Pahwa, A; Pherson, E; Sun, A; Volpicelli, F; Sreenivasan, A; Cho, HJ

Published Date

  • July 2021

Published In

Volume / Issue

  • 16 / 7

Start / End Page

  • 417 - 423

PubMed ID

  • 34197307

Electronic International Standard Serial Number (EISSN)

  • 1553-5606

Digital Object Identifier (DOI)

  • 10.12788/jhm.3637


  • eng

Conference Location

  • United States