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Mucocele-like lesions of the breast - A radiological and clinicopathological analysis.

Publication ,  Journal Article
Griffiths, R; Alarcon, L; Bonello, V; Scott, V; Szollosi, Z
Published in: Curr Probl Cancer
December 2021

INTRODUCTION: Mucocele-like lesions (MLL) of the breast are rare entities which are considered to harbor uncertain malignant potential. Current UK guidelines recommend vacuum assisted excision (VAE) of all such lesions regardless of whether they display epithelial atypia. This study sought to review the key histological and radiological features of MLLs and compare their differing outcomes based on the presence of epithelial atypia. METHODS: Pathology records of a single breast cancer screening center were retrospectively searched for all biopsy diagnosed MLLs over an 11-year period. Upgrade rates to malignancy (positive predictive values) were calculated by reviewing histology from the initial core biopsy and comparing with the corresponding excision specimen. Radiological images were simultaneously reviewed to provide radiological-pathological correlation. RESULTS: Three of 11 patients (27.3%) with atypical MLLs on biopsy had malignant outcomes at excision, compared with only 1 of 36 patients (2.8%) with non-atypical MLLs. The majority of MLLs (93%) were identified as microcalcifications on mammographic imaging. No specific radiological features were predictive of malignancy. CONCLUSIONS: Our data suggest that MLLs without atypia are potentially overtreated with current protocols and could be managed conservatively with radiological follow up. Radiological-pathological correlation is essential.

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Published In

Curr Probl Cancer

DOI

EISSN

1535-6345

Publication Date

December 2021

Volume

45

Issue

6

Start / End Page

100762

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Mucocele
  • Middle Aged
  • Mammography
  • London
  • Humans
  • Female
  • Breast Neoplasms
  • Aged, 80 and over
 

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Griffiths, R., Alarcon, L., Bonello, V., Scott, V., & Szollosi, Z. (2021). Mucocele-like lesions of the breast - A radiological and clinicopathological analysis. Curr Probl Cancer, 45(6), 100762. https://doi.org/10.1016/j.currproblcancer.2021.100762
Griffiths, Richard, Lida Alarcon, Victoria Bonello, Victoria Scott, and Zoltan Szollosi. “Mucocele-like lesions of the breast - A radiological and clinicopathological analysis.Curr Probl Cancer 45, no. 6 (December 2021): 100762. https://doi.org/10.1016/j.currproblcancer.2021.100762.
Griffiths R, Alarcon L, Bonello V, Scott V, Szollosi Z. Mucocele-like lesions of the breast - A radiological and clinicopathological analysis. Curr Probl Cancer. 2021 Dec;45(6):100762.
Griffiths, Richard, et al. “Mucocele-like lesions of the breast - A radiological and clinicopathological analysis.Curr Probl Cancer, vol. 45, no. 6, Dec. 2021, p. 100762. Pubmed, doi:10.1016/j.currproblcancer.2021.100762.
Griffiths R, Alarcon L, Bonello V, Scott V, Szollosi Z. Mucocele-like lesions of the breast - A radiological and clinicopathological analysis. Curr Probl Cancer. 2021 Dec;45(6):100762.
Journal cover image

Published In

Curr Probl Cancer

DOI

EISSN

1535-6345

Publication Date

December 2021

Volume

45

Issue

6

Start / End Page

100762

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Mucocele
  • Middle Aged
  • Mammography
  • London
  • Humans
  • Female
  • Breast Neoplasms
  • Aged, 80 and over