Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses.

Journal Article (Journal Article)

BACKGROUND AND AIMS: Observational studies have associated resting heart rate with incident diabetes. Whether the associations are causal remains unclear. We aimed to examine the shape and strength of the associations and assessed the causal relevance of such associations in Chinese adults. METHODS AND RESULTS: The China Kadoorie Biobank enrolled 512,891 adults in China. Cox proportional hazard regression models was conducted to estimate hazard ratios (HRs) for the associations of resting heart rate with type 2 diabetes and total diabetes. Among 92,724 participants, 36 single-nucleotide polymorphisms (SNPs) related to resting heart rate were used to construct genetic risk score. We used Mendelian randomization analyses to make the causal inferences. During a median follow-up of 9 years, 7872 incident type 2 diabetes and 13,349 incident total diabetes were documented. After regression dilution bias adjustment, each 10 bpm higher heart rate was associated with about a 26% higher risk of type 2 diabetes (HR, 1.26 [95% CI, 1.23, 1.29]) and 23% higher risk of total diabetes (HR, 1.23 [95% CI, 1.20, 1.26]). Instrumental variable analyses showed participants at top quintile compared with those at bottom quintile had 30% higher risk for type 2 diabetes (HR, 1.30 [95% CI, 1.17, 1.43]), and 10% higher risk for total diabetes (HR, 1.10 [95% CI, 1.02, 1.20]). CONCLUSIONS: This study provides evidence that resting heart rate is an important risk factor for diabetes risk. The results suggest that novel treatment approaches targeting reduction of high heart rate for incidence of diabetes may be worth further investigation.

Full Text

Duke Authors

Cited Authors

  • Wang, W; Wang, J; Lv, J; Yu, C; Shao, C; Tang, Y; Guo, Y; Bian, Z; Du, H; Yang, L; Millwood, IY; Walters, RG; Chen, Y; Chang, L; Fan, L; Chen, J; Chen, Z; Huang, T; Li, L; China Kadoorie Biobank Collaborative Group, ; International Steering Committee, ; International Co-ordinating Centre, Oxford, ; National Co-ordinating Centre, Beijing, ; 10 Regional Co-ordinating Centres: Qingdao CDC, ; Licang CDC, ; Heilongjiang Provincial CDC, ; Nangang CDC, ; Hainan Provincial CDC, ; Meilan CDC, ; Jiangsu Provincial CDC, ; Suzhou CDC, ; Guangxi Provincial CDC, ; Liuzhou CDC, ; Sichuan Provincial CDC, ; Pengzhou CDC, ; Gansu Provincial CDC, ; Maiji CDC, ; Henan Provincial CDC, ; Huixian CDC, ; Zhejiang Provincial CDC, ; Tongxiang CDC, ; Hunan Provincial CDC, ; Liuyang CDC,

Published Date

  • July 22, 2021

Published In

Volume / Issue

  • 31 / 8

Start / End Page

  • 2328 - 2337

PubMed ID

  • 34052074

Electronic International Standard Serial Number (EISSN)

  • 1590-3729

Digital Object Identifier (DOI)

  • 10.1016/j.numecd.2021.04.015


  • eng

Conference Location

  • Netherlands