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Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.

Publication ,  Journal Article
Markwalter, CF; Kantor, AG; Moore, CP; Richardson, KA; Wright, DW
Published in: Chemical reviews
January 2019

Infectious diseases claim millions of lives each year. Robust and accurate diagnostics are essential tools for identifying those who are at risk and in need of treatment in low-resource settings. Inorganic complexes and metal-based nanomaterials continue to drive the development of diagnostic platforms and strategies that enable infectious disease detection in low-resource settings. In this review, we highlight works from the past 20 years in which inorganic chemistry and nanotechnology were implemented in each of the core components that make up a diagnostic test. First, we present how inorganic biomarkers and their properties are leveraged for infectious disease detection. In the following section, we detail metal-based technologies that have been employed for sample preparation and biomarker isolation from sample matrices. We then describe how inorganic- and nanomaterial-based probes have been utilized in point-of-care diagnostics for signal generation. The following section discusses instrumentation for signal readout in resource-limited settings. Next, we highlight the detection of nucleic acids at the point of care as an emerging application of inorganic chemistry. Lastly, we consider the challenges that remain for translation of the aforementioned diagnostic platforms to low-resource settings.

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Published In

Chemical reviews

DOI

EISSN

1520-6890

ISSN

0009-2665

Publication Date

January 2019

Volume

119

Issue

2

Start / End Page

1456 / 1518

Related Subject Headings

  • Point-of-Care Systems
  • Nanostructures
  • Metals
  • Magnetics
  • Luminescent Measurements
  • Humans
  • General Chemistry
  • Coordination Complexes
  • Communicable Diseases
  • Biomarkers
 

Citation

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Markwalter, C. F., Kantor, A. G., Moore, C. P., Richardson, K. A., & Wright, D. W. (2019). Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics. Chemical Reviews, 119(2), 1456–1518. https://doi.org/10.1021/acs.chemrev.8b00136
Markwalter, Christine F., Andrew G. Kantor, Carson P. Moore, Kelly A. Richardson, and David W. Wright. “Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.Chemical Reviews 119, no. 2 (January 2019): 1456–1518. https://doi.org/10.1021/acs.chemrev.8b00136.
Markwalter CF, Kantor AG, Moore CP, Richardson KA, Wright DW. Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics. Chemical reviews. 2019 Jan;119(2):1456–518.
Markwalter, Christine F., et al. “Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.Chemical Reviews, vol. 119, no. 2, Jan. 2019, pp. 1456–518. Epmc, doi:10.1021/acs.chemrev.8b00136.
Markwalter CF, Kantor AG, Moore CP, Richardson KA, Wright DW. Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics. Chemical reviews. 2019 Jan;119(2):1456–1518.
Journal cover image

Published In

Chemical reviews

DOI

EISSN

1520-6890

ISSN

0009-2665

Publication Date

January 2019

Volume

119

Issue

2

Start / End Page

1456 / 1518

Related Subject Headings

  • Point-of-Care Systems
  • Nanostructures
  • Metals
  • Magnetics
  • Luminescent Measurements
  • Humans
  • General Chemistry
  • Coordination Complexes
  • Communicable Diseases
  • Biomarkers