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Dopamine agonists and the suppression of impulsive motor actions in Parkinson disease.

Publication ,  Journal Article
Wylie, SA; Claassen, DO; Huizenga, HM; Schewel, KD; Ridderinkhof, KR; Bashore, TR; van den Wildenberg, WPM
Published in: Journal of cognitive neuroscience
August 2012

The suppression of spontaneous motor impulses is an essential facet of cognitive control that is linked to frontal-BG circuitry. BG dysfunction caused by Parkinson disease (PD) disrupts the proficiency of action suppression, but how pharmacotherapy for PD impacts impulsive motor control is poorly understood. Dopamine agonists improve motor symptoms of PD but can also provoke impulsive-compulsive behaviors (ICB). We investigated whether dopamine agonist medication has a beneficial or detrimental effect on impulsive action control in 38 PD patients, half of whom had current ICB. Participants performed the Simon conflict task, which measures susceptibility to acting on spontaneous action impulses as well as the proficiency of suppressing these impulses. Compared with an off-agonist state, patients on their agonists were no more susceptible to reacting impulsively but were less proficient at suppressing the interference from the activation of impulsive actions. Importantly, agonist effects depended on baseline performance in the off-agonist state; more proficient suppressors off agonist experienced a reduction in suppression on agonist, whereas less-proficient suppressors off agonist showed improved suppression on agonist. Patients with active ICB were actually less susceptible to making fast, impulsive response errors than patients without ICB, suggesting that behavioral problems in this subset of patients may be less related to impulsivity in motor control. Our findings provide further evidence that dopamine agonist medication impacts specific cognitive control processes and that the direction of its effects depends on individual differences in performance off medication.

Duke Scholars

Published In

Journal of cognitive neuroscience

DOI

EISSN

1530-8898

ISSN

0898-929X

Publication Date

August 2012

Volume

24

Issue

8

Start / End Page

1709 / 1724

Related Subject Headings

  • Severity of Illness Index
  • Parkinson Disease
  • Neuropsychological Tests
  • Motor Activity
  • Male
  • Individuality
  • Impulsive Behavior
  • Humans
  • Female
  • Experimental Psychology
 

Citation

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Wylie, S. A., Claassen, D. O., Huizenga, H. M., Schewel, K. D., Ridderinkhof, K. R., Bashore, T. R., & van den Wildenberg, W. P. M. (2012). Dopamine agonists and the suppression of impulsive motor actions in Parkinson disease. Journal of Cognitive Neuroscience, 24(8), 1709–1724. https://doi.org/10.1162/jocn_a_00241
Wylie, Scott A., Daniel O. Claassen, Hilde M. Huizenga, Kerilyn D. Schewel, K Richard Ridderinkhof, Theodore R. Bashore, and Wery P. M. van den Wildenberg. “Dopamine agonists and the suppression of impulsive motor actions in Parkinson disease.Journal of Cognitive Neuroscience 24, no. 8 (August 2012): 1709–24. https://doi.org/10.1162/jocn_a_00241.
Wylie SA, Claassen DO, Huizenga HM, Schewel KD, Ridderinkhof KR, Bashore TR, et al. Dopamine agonists and the suppression of impulsive motor actions in Parkinson disease. Journal of cognitive neuroscience. 2012 Aug;24(8):1709–24.
Wylie, Scott A., et al. “Dopamine agonists and the suppression of impulsive motor actions in Parkinson disease.Journal of Cognitive Neuroscience, vol. 24, no. 8, Aug. 2012, pp. 1709–24. Epmc, doi:10.1162/jocn_a_00241.
Wylie SA, Claassen DO, Huizenga HM, Schewel KD, Ridderinkhof KR, Bashore TR, van den Wildenberg WPM. Dopamine agonists and the suppression of impulsive motor actions in Parkinson disease. Journal of cognitive neuroscience. 2012 Aug;24(8):1709–1724.
Journal cover image

Published In

Journal of cognitive neuroscience

DOI

EISSN

1530-8898

ISSN

0898-929X

Publication Date

August 2012

Volume

24

Issue

8

Start / End Page

1709 / 1724

Related Subject Headings

  • Severity of Illness Index
  • Parkinson Disease
  • Neuropsychological Tests
  • Motor Activity
  • Male
  • Individuality
  • Impulsive Behavior
  • Humans
  • Female
  • Experimental Psychology