Comparative efficacy and safety of late surfactant preparations: a retrospective study.

Journal Article (Journal Article)

OBJECTIVE: Characterize the use, efficacy, and safety of poractant alfa and calfactant surfactants compared to beractant in preterm infants receiving late surfactant. STUDY DESIGN: We included infants <37 weeks gestational age (GA) discharged from Pediatrix Medical Group-managed neonatal intensive care units (1997-2017). Efficacy and safety outcomes of interest were analyzed. RESULTS: Of 184,770 infants administered surfactant at any time, 7846 (4.23%) received late surfactant at a median (25th, 75th percentile) PNA of 8 days (3, 22); specifically, 2976 received poractant alfa (38%), 2890 beractant (37%), and 1936 calfactant (25%). We identified no significant differences in composite efficacy or safety outcomes between surfactants in the primary analysis, but 33-36 week GA infants administered poractant alfa had significantly greater odds of developing a safety event. CONCLUSIONS: Compared to beractant, there is no evidence of overall superior efficacy or safety of poractant alfa.

Full Text

Duke Authors

Cited Authors

  • Lane, MD; Kishnani, S; Udemadu, O; Danquah, SE; Treadway, RM; Langman, A; Balevic, S; Jackson, WM; Laughon, M; Hornik, CP; Greenberg, RG; Clark, RH; Zimmerman, KO

Published Date

  • November 2021

Published In

Volume / Issue

  • 41 / 11

Start / End Page

  • 2639 - 2644

PubMed ID

  • 34285358

Pubmed Central ID

  • PMC8290378

Electronic International Standard Serial Number (EISSN)

  • 1476-5543

Digital Object Identifier (DOI)

  • 10.1038/s41372-021-01142-2

Language

  • eng

Conference Location

  • United States